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Structure of the PRKD genes. Cysteine-rich regulatory domains (red; C); pleckstrinhomology domain (purple; PH); protein kinase domain (green; PKD). Exonic breakpoints found in our cohort denoted by hashed black bars (exons 11, 12 and 13 in PRKD1; exons 10 and 11 in PRKD2; exons 10 and 13 in PRKD3). Terminal codons and E710 hot-spot indicated in gray (21)(22).
