Fig 3. Erosive arthritis severity and progression occurs in a bone-dependent and sexually dimorphic manner.

To visualize the bone-specific effects within the compartments of the hindpaw (A), we plotted the mean percent change from 2-month baseline bone volumes for each individual bone as heatmaps (B-F). Note the accelerated onset of bone erosions in female mice across each compartment of the hindpaw, along with the variable arthritic progression between bones, most notable in the tarsal region (B). Representative micro-CT images of the bones within each compartment across time are provided in S3–S9 Figs.