Table 3.
Frequency of Adverse Events of Patients With Good-Grade and Poor-Grade aSAH According to the As-Treated Principle
| Good-grade aSAH WFNS I-III (N = 473) |
Poor-grade aSAH WFNS IV-V (N = 338) |
|||||
| TXA group (N = 232) | Usual care group (N = 241) | OR (95% CI) | TXA group (N = 162) | Usual care group (N = 176) | OR (95% CI) | |
| All rebleedings before aneurysm treatment | 24 (10) | 31 (13) | 0.78 (0.44–1.38) | 22 (14) | 34 (19) | 0.66 (0.37–1.18) |
| CT-proven rebleedings before aneurysm treatment | 23 (10) | 29 (12) | 0.80 (0.45–1.44) | 15 (9) | 28 (16) | 0.54 (0.28–1.05) |
| Hydrocephalus | 138 (60) | 121 (50) | 1.46 (1.01–2.10) | 112 (69) | 126 (72) | 0.89 (0.56–1.42) |
| Delayed cerebral ischemia | 60 (26) | 60 (25) | 1.05 (0.70–1.59) | 38 (24) | 48 (27) | 0.81 (0.50–1.33) |
| Thromboembolic complications during endovascular treatment | 18 (11) | 24 (14) | 0.73 (0.38–1.40) | 11 (11) | 9 (9) | 1.24 (0.49–3.13) |
| Cerebral infarction related to clipping procedure | 14 (28) | 9 (16) | 2.12 (0.83–5.43) | 8 (27) | 9 (14) | 1.05 (0.35–3.18) |
| Per-procedural rupture | ||||||
| Coiling | 8 (5) | 7 (4) | 1.17 (0.41–3.29) | 7 (7) | 6 (6) | 1.17 (0.38–3.61) |
| Clipping | 9 (18) | 15 (26) | 0.63 (0.25–1.60) | 7 (23) | 8 (22) | 1.07 (0.34–3.38) |
| Extracranial thrombosisa | 3 (1) | 1 (0) | 3.14 (0.33–30.5) | 2 (1) | 6 (3) | 0.35 (0.70–1.78) |
| Hemorrhagic complication | 14 (6) | 18 (8) | 0.80 (0.39–1.64) | 12 (8) | 16 (9) | 0.81 (0.37–1.76) |
| Severe hyponatraemia | 7 (3) | 7 (3) | 1.04 (0.36–3.01) | 4 (3) | 1 (1) | 4.43 (0.49–40.1) |
| Pneumonia | 19 (8) | 30 (12) | 0.63 (0.34–1.15) | 32 (20) | 38 (22) | 0.89 (0.53–1.52) |
| Infectious meningitis | 18 (8) | 19 (8) | 0.98 (0.50–1.92) | 9 (6) | 13 (7) | 0.74 (0.31–1.78) |
| Urinary tract infection | 21 (9) | 33 (14) | 0.63 (0.35–1.12) | 15 (9) | 9 (5) | 1.89 (0.81–4.46) |
| Seizure | 24 (10) | 24 (10) | 1.04 (0.57–1.90) | 28 (17) | 17 (10) | 1.95 (1.03–3.73) |
| Delirium | 31 (13) | 33 (14) | 0.97 (0.57–1.65) | 23 (14) | 23 (13) | 1.10 (0.59–2.05) |
Data presented as n (%), unless noted otherwise. Odds ratio (OR), adjusted odds ratio (aOR), 95% confidence interval (95% CI). The as-treated analyses included 811 patients (n = 1 patient of whom it was unknown whether TXA was administered or not).
Missing data in poor grade aSAH: delayed cerebral ischemia, N = 1 missing, cerebral infarction related to clipping procedure, N = 1 missing, and hemorrhagic complication, N = 1 missing.
a
Extracranial thrombosis includes deep venous thrombosis and pulmonary embolism.