Table 2.
Associations Between Serum and CSF Levels of Complement Components and Medium-Term Disability Progression
| Components | Univariable OR (95% CI); p value | Multivariable OR (95% CI); p value | Components | Univariable OR (95% CI); p value | Multivariable OR (95% CI); p value |
| Serum | CSF | ||||
| Ba (ng/mL) | 1.21 (0.48–3.47); 0.699 | 1.06 (0.36–3.43); 0.921 | Ba (ng/mL) | 1.45 (0.78–2.75); 0.241 | 1.17 (0.53–2.49); 0.679 |
| Bb (μg/mL) | 2.08 (1.03–4.56); 0.049 | 1.51 (0.68–3.59); 0.319 | Bb (μg/mL) | 1.48 (0.65–3.32); 0.329 | 0.67 (0.17–2.27); 0.538 |
| C3a (ng/mL) | 1.48 (0.83–2.89); 0.214 | 1.32 (0.69–2.78); 0.419 | C3a (ng/mL) | 1.26 (0.79–1.99); 0.322 | 1.12 (0.61–2.12); 0.706 |
| C4a (ng/mL) | 1.43 (0.92–2.30); 0.117 | 1.59 (0.92–2.97); 0.114 | C4a (ng/mL) | 0.90 (0.51–1.56); 0.714 | 1.08 (0.50–2.33); 0.835 |
| C5a (ng/mL) | 1.56 (0.96–2.65); 0.081 | 1.38 (0.76–2.59); 0.296 | C5a (ng/mL) | 1.42 (0.93–2.27); 0.113 | 1.05 (0.60–1.87); 0.856 |
| Factor H (μg/mL) | 0.47 (0.08–2.35); 0.360 | 1.2 (0.10–16.84); 0.886 | Factor H (μg/mL) | 0.24 (0.02–1.94); 0.189 | 0.10 (0.00–2.73); 0.191 |
| Factor I (ng/mL) | 0.86 (0.41–1.80); 0.686 | 1.25 (0.52–3.13); 0.621 | Factor I (ng/mL) | 1.08 (0.30–3.51); 0.901 | 1.23 (0.16–8.96); 0.839 |
| SC5b9 (ng/mL) | 1.23 (0.69–2.26); 0.487 | 1.06 (0.54–2.17); 0.863 | SC5b9 (ng/mL) | 0.97 (0.52–1.78); 0.912 | 0.88 (0.37–1.99); 0.762 |
| C1q (μg/mL) | 0.38 (0.04–3.12); 0.364 | 0.31 (0.02–5.03); 0.405 | C1q (μg/mL) | 0.44 (0.21–0.83); 0.015 | 0.43 (0.17–0.98); 0.054 |
| C3 (μg/mL) | 0.61 (0.34–1.08); 0.091 | 0.45 (0.19–0.93); 0.050 | C3 (μg/mL) | 0.23 (0.02–2.45); 0.222 | 0.08 (0.00–1.31); 0.076 |
| C4 (μg/mL) | 1.36 (0.96–1.97); 0.090 | 1.16 (0.74–1.83); 0.516 | C4 (μg/mL) | 0.73 (0.45–1.19); 0.186 | 0.70 (0.36–1.32); 0.265 |
| C5 (μg/mL) | 0.77 (0.15–3.91); 0.748 | 0.92 (0.13–6.07); 0.927 | C5 (μg/mL) | 0.70 (0.41–1.19); 0.189 | 0.65 (0.28–1.45); 0.295 |
| C3a/C3 ratio | 2.03 (1.18–3.91); 0.018 | 2.30 (1.17–6.03); 0.040 | C3a/C3 ratio | 1.32 (0.84–2.10); 0.224 | 1.24 (0.69–2.34); 0.483 |
| C4a/C4 ratio | 0.91 (0.60–1.30); 0.606 | 1.27 (0.74–2.39); 0.408 | C4a/C4 ratio | 1.09 (0.80–1.46); 0.553 | 1.17 (0.79–1.73); 0.424 |
| C5a/C5 ratio | 1.47 (0.95–2.33); 0.091 | 1.29 (0.77–2.23); 0.336 | C5a/C5 ratio | 1.34 (0.99–1.84); 0.063 | 1.12 (0.77–1.64); 0.541 |
OR represents multiplicative effects of doubling of each complement component. Multivariable analysis was adjusted by age, sex, and Qalb. Table 2 only shows the results for the complement components. Results for the remaining variables included in the multivariable analysis are shown in online eTables 8 and 9. OR = odds ratio.