Table 3.
Associations Between Serum and CSF Levels of Complement Components and Long-Term Disability Progression
| Components | Univariable OR (95% CI); p value | Multivariable OR (95% CI); p value | Components | Univariable OR (95% CI); p value | Multivariable OR (95% CI); p value |
| Serum | CSF | ||||
| Ba (ng/mL) | 1.05 (0.48–2.46); 0.896 | 0.87 (0.37–2.14); 0.751 | Ba (ng/mL) | 1.34 (0.79–2.30); 0.277 | 1.32 (0.71–2.45); 0.373 |
| Bb (μg/mL) | 1.59 (0.90–2.91); 0.120 | 1.28 (0.67–2.54); 0.455 | Bb (μg/mL) | 1.25 (0.65–2.33); 0.487 | 0.90 (0.36–2.07); 0.802 |
| C3a (ng/mL) | 1.51 (0.93–2.65); 0.120 | 1.36 (0.79–2.53); 0.289 | C3a (ng/mL) | 1.11 (0.75–1.61); 0.590 | 1.08 (0.66–1.73); 0.753 |
| C4a (ng/mL) | 1.25 (0.85–1.85); 0.258 | 1.24 (0.80–1.95); 0.340 | C4a (ng/mL) | 1.04 (0.64–1.69); 0.870 | 1.34 (0.74–2.49); 0.330 |
| C5a (ng/mL) | 1.34 (0.89–2.06); 0.161 | 1.25 (0.77–2.09); 0.373 | C5a (ng/mL) | 1.12 (0.78–1.62); 0.522 | 0.92 (0.57–1.46); 0.719 |
| Factor H (μg/mL) | 0.96 (0.20–4.46); 0.954 | 0.53 (0.05–4.83); 0.574 | Factor H (μg/mL) | 0.43 (0.06–2.71); 0.371 | 0.34 (0.02–4.87); 0.427 |
| Factor I (ng/mL) | 0.86 (0.44–1.67); 0.666 | 0.83 (0.37–1.80); 0.634 | Factor I (ng/mL) | 1.00 (0.32–2.92); 0.996 | 1.03 (0.18–5.24); 0.974 |
| SC5b9 (ng/mL) | 1.05 (0.65–1.73); 0.845 | 0.95 (0.55–1.67); 0.858 | SC5b9 (ng/mL) | 1.13 (0.65–1.98); 0.667 | 1.11 (0.56–2.21); 0.763 |
| C1q (μg/mL) | 0.49 (0.08–3.04); 0.438 | 0.39 (0.05–3.12); 0.367 | C1q (μg/mL) | 0.47 (0.25–0.85); 0.015 | 0.41 (0.17–0.86); 0.025 |
| C3 (μg/mL) | 0.68 (0.40–1.15); 0.150 | 0.61 (0.33–1.09); 0.105 | C3 (μg/mL) | 0.38 (0.05–3.06); 0.356 | 0.32 (0.03–3.18); 0.318 |
| C4 (μg/mL) | 1.24 (0.92–1.71); 0.168 | 1.19 (0.83–1.73); 0.334 | C4 (μg/mL) | 0.82 (0.57–1.19); 0.276 | 0.82 (0.54–1.24); 0.328 |
| C5 (μg/mL) | 0.81 (0.22–3.03); 0.754 | 0.67 (0.15–2.84); 0.590 | C5 (μg/mL) | 0.78 (0.49–1.22); 0.267 | 0.71 (0.37–1.34); 0.289 |
| C3a/C3 ratio | 1.87 (1.17–3.26); 0.015 | 1.81 (1.09–3.40); 0.037 | C3a/C3 ratio | 1.14 (0.78–1.63); 0.490 | 1.12 (0.71–1.74); 0.626 |
| C4a/C4 ratio | 0.91 (0.64–1.26); 0.599 | 0.96 (0.62–1.45); 0.838 | C4a/C4 ratio | 1.09 (0.86–1.38); 0.442 | 1.15 (0.88–1.50); 0.286 |
| C5a/C5 ratio | 1.26 (0.89–1.82); 0.195 | 1.21 (0.80–1.88); 0.367 | C5a/C5 ratio | 1.14 (0.89–1.46); 0.295 | 1.04 (0.77–1.41); 0.788 |
OR represents multiplicative effects of doubling of each complement component. Multivariable analysis was adjusted by age, sex, and Qalb. Table 3 only shows the results for the complement components. Results for the remaining variables included in the multivariable analysis are shown in online eTables 11 and 12. OR = odds ratio.