Table 3.
Drugs Associated With a Changed Incidence of Aneurysmal Subarachnoid Hemorrhage Incidence Using a Binomial Logistic Regression Model and Bonferroni Corrected 95% CIs for Use vs Nonuse of the Same Drug
| Read code | Drug name | Current use OR (95% CI) |
Recent use OR (95% CI) |
Past use OR (95% CI) |
| Decreased incidence | ||||
| bi3 | Lisinopril | 0.63a (0.44–0.90) | 1.30 (0.61–2.78) | 1.04 (0.75–1.45) |
| bxd | Simvastatin | 0.78a (0.64–0.96) | 0.95 (0.62–1.45) | 0.84 (0.68–1.04) |
| f41 | Metformin | 0.58a (0.43–0.78) | 1.01 (0.45–2.25) | 0.71 (0.43–1.18) |
| gc7 | Tamsulosin | 0.55a (0.32–0.93) | 2.0 (0.90–4.43) | 0.94 (0.58–1.53) |
| Increased incidence | ||||
| blb | Amlodipine | 0.82 (0.65–1.04) | 1.61a (1.04–2.48) | 1.07 (0.84–1.37) |
| bs1 | Warfarin | 1.35a (1.02–1.79) | 1.54 (0.76–3.13) | 1.08 (0.69–1.69) |
| da7 | Venlafaxine | 1.67a (1.01–2.75) | 1.13 (0.35–3.64) | 1.1 (0.76–1.59) |
| dhe | Prochlorperazine [nausea] | 2.15a (1.45–3.18) | 1.04 (0.68–1.58) | 0.99 (0.83–1.19) |
| dia2 | Co-codamol | 1.31a (1.10–1.56) | 1.12 (0.90–1.4) | 1.00 (0.87–1.15) |
Abbreviation: OR = odds ratio.
a
Statistically significant (p < 0.05) after Bonferroni correction. Time windows are defined as current (within 3 months before index date), recent (between 1 year before index date and 3 months before index date), and past (between January 1, 2000, and 1 year before index date).