Table 1.

Overview of the POKAL-PSY study

Study goal

Development of a machine learning algorithm based on relevant risk-factors and predictors to facilitate the diagnosis of depression

Study design

Prospective Study with three cohorts

Inclusion criteria

Sufficient ability to speak and understand German

Female and male subjects between 18–70 years

Ability to understand and sign the informed consent form

PHQ > 8, if depressed

Exclusion criteria

Cognitive limitations that interfere with reliable completion of questionnaires

Presence of a manic episode, bipolar disorder, schizophrenia spectrum disorder, active eating disorder, drug or alcohol dependence syndrome

Presence of uncontrolled systemic disease, uncontrolled somatic (other than metabolic or cardiovascular) /neurologic disease, current or recent (last month) trauma or infectious disease

Patients with acute suicidal ideation

Alpha-1-Antitrypsin deficiency

Pregnant or lactating women

Discontinuation criteria

Patients will be excluded if they develop an exclusion criterion during the course of the study. Data collected up to that point will be retained. The data collected up to that point will be retained in anonymized form, unless the participant requests deletion before ceasing their study participation