Table 2.

Study assessment overview

	Study inclusion	After 4 weeks	Yearly follow up until 5 years
Observer rating	MADRS, GAF SIMPAQ, expert rating, SCID-CV	MADRS, GAF SIMPAQ	MADRS, GAF SIMPAQ, expert rating,
Self-rating questionnaires	Large questionnaire profile1	Small questionnaire profile2	Large questionnaire profile1
HRV measurements	At least 10 min (5 min supine/sitting each)	At least 10 min (5 min supine/sitting each)	At least 10 min (5 min supine/sitting each)
Bioimpedance scale	Tanita scale	Tanita scale	Tanita Scale
Laboratory assessments	Multiplex analysis, blood collection3	Multiplex analysis, blood collection3	Blood collection3
Vital parameters	Blood pressure, temperature, pulse	Blood pressure, temperature, pulse	Blood pressure, temperature, pulse

Large questionnaire profile¹: socio-demographic data, family history, medical history, PHQ-9, PHQ-15, MCTQ, GAD-7, postal code, PID5BF + M, WHO-DAS, FEV, CTS, CTQ, PC-PTSD, PACIC, FEV, WHO-5, LSNS 6, BRS, UCLA LS 3, SSD-12, IDS-SR small questionnaire profile²: HTQ, PHQ-9, PHQ-15, MCTQ, GAD-7, WHO-DAS, FEV, SSD-12, IDS-SR Blood Collection³: fasting glucose, triglycerides, morning cortisol, CRP, AAT-1, IGF-1, cortisol, TSH, complete blood count, HbA1c, liver values