Table 2.
Medication use before and during pregnancy (n = 19,297)
| Prior to pregnancy diagnosisa | From diagnosis to week 12a | Post week 12 of pregnancya | ||||||
|---|---|---|---|---|---|---|---|---|
| General name | n | % | General name | n | % | General name | n | % |
| Loxoprofen sodium hydrate | 1064 | 5.5 | Magnesium oxide | 1,138 | 5.9 | Ritodrine hydrochloride | 2024 | 10.5 |
| l-Carbocisteine | 815 | 4.2 | Acetaminophen | 747 | 3.9 | Magnesium oxide | 1910 | 9.9 |
| Acetaminophen | 663 | 3.4 | Piperidolate hydrochloride | 544 | 2.8 | Sodium ferrous citrate | 1054 | 5.5 |
| Tranexamic acid | 561 | 2.9 | Ritodrine hydrochloride | 471 | 2.4 | Acetaminophen | 663 | 3.4 |
| Clarithromycin | 481 | 2.5 | Tranexamic acid | 361 | 1.9 | Sodium picosulfate hydrate | 404 | 2.1 |
| Fexofenadine hydrochloride | 422 | 2.2 | Sodium ferrous citrate | 310 | 1.6 | Shoseiryuto extract | 294 | 1.5 |
| Salicylamide, acetaminophen, anhydrous caffeine, and promethazine methylenedisalicylate | 350 | 1.8 | l-Carbocisteine | 272 | 1.4 | l-Carbocisteine | 286 | 1.5 |
| Cefcapene pivoxil hydrochloride hydrate | 336 | 1.7 | Sodium picosulfate hydrate | 271 | 1.4 | Sennosides | 269 | 1.4 |
| Clomifene citrate | 324 | 1.7 | Carbazochrome sodium sulfonate hydrate | 270 | 1.4 | Heparinoid | 209 | 1.1 |
| Rebamipide | 323 | 1.7 | Shoseiryuto extract | 262 | 1.4 | Hydrocortisone and killed Escherichia coli suspension | 176 | 0.9 |
| Magnesium oxide | 311 | 1.6 | Heparinoid | 213 | 1.1 | Hydrocortisone and killed Escherichia coli suspension | 176 | 0.9 |
| Olopatadine hydrochloride | 288 | 1.5 | Kakkonto extract | 213 | 1.1 | Salicylamide, acetaminophen, anhydrous caffeine, and promethazine methylenedisalicylate | 174 | 0.9 |
| Heparinoid | 255 | 1.3 | Isoxsuprine hydrochloride | 197 | 1.0 | Bifidobacterium | 174 | 0.9 |
| Levofloxacin hemihydrate | 255 | 1.3 | Salicylamide, acetaminophen, anhydrous caffeine, and promethazine methylenedisalicylate | 166 | 0.9 | Dimemorfan phosphate | 165 | 0.9 |
| Cefditoren pivoxil | 249 | 1.3 | Aspirin and dialuminate; aspirin, aluminium glycinate, and magnesium carbonate | 163 | 0.8 | Kakkonto extract | 162 | 0.8 |
aWe analysed data from the following three periods: (1) 12 months prior to pregnancy diagnosis (prior to pregnancy diagnosis), (2) the period between pregnancy diagnosis and around week 12 of pregnancy (from diagnosis to week 12), and (3) post around week 12 of pregnancy (post week 12 of pregnancy)