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. 2000 Aug;74(16):7478–7484. doi: 10.1128/jvi.74.16.7478-7484.2000

TABLE 1.

Wild-type MVs (strains IV, JW, Bcl94, and FV93) induce 10- to 80-fold less IFN-α/β than do the attenuated Edmonston, Moraten, or Vero cell-adapted IV, JW, Bcl, and FV virus strainsa

Virus strain IU of IFN/ml of supernatant
Expt 1 Expt 2
NI 250 120
Edmonston 2,000 4,000
Moraten 5,000 10,000
JW 120 120
IV 120 250
Bcl94 120 120
FV93 120 250
IV-Vero 10,000 1,250
JW-Vero 2,500 10,000
Bcl-Vero 1,250 2,000
FV-Vero 1,250 2,000
a

Virus-free supernatants from cells infected with different MV strains were assayed for the biological activity of IFN-α/β. JW and IV are wild-type MV isolates passaged solely on human PBMC, while Bcl94 and FV93 were isolated and passaged on the B958 marmoset cell line. The Edmonston and Moraten MV strains are highly attenuated and were passaged on the monkey Vero cell line. IV-, JW-, Bcl-, and FV-Vero are the wild-type viruses passaged 10 times on Vero cells. NI, noninfected cells.