Table 2.

The impact of the various bases used in the model reaction on the yield of compound 3.

Reaction No	base	solvent [1 mL]	yield [%]*
1	K2CO3	DMF	96
2		ACN	99
3		water	97
4	NaOH	DMF	6
5		ACN	44
6		water	100
7	KOH	DMF	4
8		ACN	35
9		water	93
10	TEA	DMF	59
11		ACN	91
12		water	95
13	PS	DMF	40
14	DABCO	DMF	70
15		ACN	64
16		water	60
17	Na2CO3	DMF	59
18		ACN	100
19		water	98
20	DIPEA	DMF	61
21		ACN	90
22		water	94
23	pyridine	DMF	31
24		ACN	96
25		water	100
26	NH3 aq.	DMF	85
27		ACN	81
28		water	83
29	DBU	DMF	81
30		ACN	90
31		water	63

* Yield determined by the analysis of the post-reaction mixture composition using LC-MS;