. 2024 Jun 3;6(1):e240002. doi: 10.1530/VB-24-0002
This work is licensed under a Table 1.
Characteristics of ApoE− /− Fbn1C1039G/+ mouse fed a western-type diet supplemented with 50 mg α-tocopherol or 500 mg α-tocopherol per kg diet. Data presented as mean ± s.e.m.
| 50 mg/kg diet | 500 mg/kg diet | |
|---|---|---|
| General (n = 26–31) | ||
| Body weight (g) | 22 ± 1 | 21 ± 1 |
| Spleen weight (mg) | 210 ± 17 | 275 ± 24a |
| Lung weight (mg) | 241 ± 7 | 253 ± 10 |
| Kidney weight (mg) | 163 ± 4 | 172 ± 7 |
| Circulating leukocyte subsets (n = 11–17) | ||
| T cells (%) | 22 ± 2 | 24 ± 4 |
| B cells (%) | 51 ± 3 | 49 ± 5 |
| Ly6low monocytes (%) | 10 ± 1 | 10 ± 2 |
| Ly6high monocytes (%) | 7.8 ± 0.6 | 7.0 ± 0.5 |
| Neutrophils (%) | 12 ± 1 | 15 ± 3 |
| Plaque analysis in RCCA (n = 10–16) | ||
| Plaque formation index (%) | 55 ± 7 | 21 ± 5c |
| Plaque thickness (µm) | 686 ± 54 | 381 ± 47c |
| Necrotic core area (%) | 4.0 ± 1.0 | 1.1 ± 0.5a |
| Macrophages (%) | 18 ± 4 | 26 ± 5 |
| Vascular SMCs (%) | 4 ± 1 | 5 ± 1 |
| Total collagen (%) | 23 ± 3 | 25 ± 3 |
| ICAM-1-positive ECs (%) | 81 ± 4 | 94 ± 4b |
| VCAM-1-positive ECs (%) | 44 ± 7 | 58 ± 10 |
| Cleaved caspase 3 (%) | 0.10 ± 0.03 | 0.03 ± 0.01a |
Independent samples t-test.
aP < 0.05, bP < 0.01, cP < 0.001 vs 50 mg/kg diet.
RCCA, right common carotid artery; SMCs, smooth muscle cells.