. 2024 Jun 3;6(1):e240002. doi: 10.1530/VB-24-0002
This work is licensed under a Table 2.
Cardiac parameters of ApoE−/− Fbn1C1039G/+ mouse treated with a western-type diet (WD) supplemented with 50 mg or 500 mg α-tocopherol per kg diet. Data are presented as mean ± s.e.m.
| Cardiac parameters | 0 weeks WD | 12 weeks WD | 18 weeks WD | 24 weeks WD | ||||
|---|---|---|---|---|---|---|---|---|
| 50 | 500 | 50 | 500 | 50 | 500 | 50 | 500 | |
| HW/BW (10−3)a | NA | NA | NA | NA | NA | NA | 9.6 ± 0.6 | 8.4 ± 0.3c |
| PWV (m/s)b | 2.2 ± 0.2 | 2.0 ± 0.1 | 2.5 ± 0.3 | 2.6 ± 0.5 | 2.6 ± 0.3 | 3.0 ± 0.4 | 2.5 ± 0.3 | 2.3 ± 0.3 |
| EF (%)b | 75 ± 2 | 71 ± 3 | 68 ± 3 | 76 ± 3 | 64 ± 4 | 71 ± 2 | 58 ± 3 | 68 ± 2c |
| FS (%)b | 43 ± 2 | 39 ± 2 | 38 ± 2 | 45 ± 3d | 36 ± 3 | 40 ± 2 | 31 ± 2 | 37 ± 2c |
| IVSd (mm)b | 0.93 ± 0.03 | 0.97 ± 0.04 | 0.99 ± 0.04 | 1.00 ± 0.05 | 1.04 ± 0.05 | 1.00 ± 0.03 | 1.04 ± 0.04 | 1.00 ± 0.04 |
| IVSs (mm)b | 1.5 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 |
| LVIDd (mm)b | 3.0 ± 0.1 | 3.0 ± 0.1 | 3.3 ± 0.1 | 3.1 ± 0.2 | 3.7 ± 0.2 | 3.2 ± 0.1c | 3.7 ± 0.2 | 3.3 ± 0.2c |
| LVIDs (mm)b | 1.7 ± 0.1 | 1.7 ± 0.1 | 2.1 ± 0.1 | 1.7 ± 0.2 | 2.5 ± 0.2 | 2.0 ± 0.1c | 2.6 ± 0.2 | 2.2 ± 0.1c |
| LVPWd (mm)b | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.6 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.6 ± 0.1c |
| LVPWs (mm)b | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 |
aIndependent samples t-test; bTwo-way ANOVA followed by post hoc Bonferroni’s test; cP < 0.05; dP < 0.01 vs 50 mg/kg diet, n = 21–29 for each group.
BW, body weight; EF, ejection fraction; FS, fractional shortening; HW, heart weight; IVSs, IVS during systole; IVSd, interventricular septum during diastole; LVIDd, left ventricular internal diameter during diastole; LVIDs, LVID during systole; LVPWd, left ventricular posterior wall thickness during diastole; LVPWs, LVPW during systole; NA, not applicable; PWV, pulse wave velocity.