Table 4. Adjusted Models Examining Associations Between PE and FGR With 24-Month Corrected Age Developmental Outcomesa.
Measure and outcome | B (SE) [95% CI] | P value |
---|---|---|
Bayley Scales of Infant and Toddler Development, Third Edition | ||
Cognitive | ||
PE | 3.43 (1.65) [−0.19 to 6.66] | .04 |
FGR | −8.61 (2.44) [−13.33 to −3.89] | <.001b |
Language | ||
PE | 3.92 (1.77) [0.44 to 7.39] | .03 |
FGR | −8.29 (2.38) [−12.95 to −3.63] | <.001b |
Motor | ||
PE | 1.86 (1.84) [−1.74 to 5.47] | .31 |
FGR | −7.60 (2.52) [−12.40 to −2.66] | .003b |
Child Behavior Checklist/Preschool 1.5-5 | ||
Internalizing | ||
PE | −0.08 (1.36) [−2.58 to 2.73] | .96 |
FGR | 4.12 (1.79) [0.60 to 7.63] | .02 |
Externalizing | ||
PE | 0.69 (1.25) [−1.76 to 3.15] | .58 |
FGR | 2.14 (1.83) [−1.46 to 5.73] | .24 |
Total | ||
PE | 0.21 (1.37) [−2.48 to 2.91] | .88 |
FGR | 3.06 (1.85) [−0.57 to 6.68] | .10 |
Abbreviations: FGR, fetal growth restriction; PE, preeclampsia.
Adjusted models nested infants within multiple-birth families and site. Adjusted models controlled for infant biologic sex, gestational age, hypoaroused and hyperaroused neurobehavior on the NICU Network Neurobehavioral Scale, cumulative medical morbidities on the Bassler index,28 partner status, low socioeconomic status based on maternal education and occupation, chorioamnionitis, antenatal steroids, maternal prepregnancy obesity, and maternal age at birth.
Significant at Bonferroni adjusted α = .008.