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Table 1.

Baseline characteristics of mother–child dyads. Data are presented as mean ± s.d.or median (25th; 75th percentile) for continuous variables or as n (%) for categorical variables. Values in bold indicate statistical significance.

All (n = 735) Girls (n = 352) Boys (n = 383) P*
Maternal characteristics
 Maternal age (years) 30.3 ± 4.5 30.2 ± 4.3 30.4 ± 4.7 0.57
 Pre-pregnancy BMI (kg/m2) 23.4 (21.3;26.6) 22.8 (21.1;26.0) 23.8 (21.5;27.1) 0.003
 Parity 0.31
  Nulliparous 436 (59.3) 202 (57.4) 234 (61.1)
  Primi- and multi-parous 299 (40.7) 150 (42.6) 149 (38.9)
 Smoking 0.69
  Yes 25 (3.4) 11 (3.1) 14 (3.7)
  No 710 (96.6) 341 (96.9) 369 (96.3)
 Education 0.29
  Low 207 (28.2) 91 (25.8) 116 (30.3)
  Intermediate 373 (50.8) 179 (50.9) 194 (50.6)
  High 147 (20.0) 77 (21.9) 70 (18.3)
  Missing 8 (1.0) 5 (1.4) 3 (0.8)
 Ethnicity 0.93
  European 708 (96.3) 341 (96.9) 367 (95.8)
  Non-European 17 (2.3) 8 (2.3) 9 (2.4)
  Missing information 10 (1.4) 3 (0.8) 7 (1.8)
 Thyroid status
  TPOAb ≥11.0 (kIU/L) 52.6 (24.0;149.5) 42.6 (23.1;137.0) 83.5 (24.8;159.0) 0.18
   n (%) 88 (12.0) 46 (13.1) 42 (11.0)
  TPOAb <11.0 (kIU/L) 647 (88.0) 306 (47.3) 341 (52.7) 1.00
  FT4 (pmol/L) 14.12 ± 1.91 14.27 ± 2.02 13.99 ± 1.79 0.03
  TSH (mIU/L) 1.43 (0.92;2.06) 1.41 (0.88;1.92) 1.46 (0.93;2.16) 0.29
Offspring characteristics
 Gestational age (days) 282 (276;288) 282 (275;287) 281 (274;287) 0.51
 Birth weight (g) 3567 ± 473 3501 ± 457 3628 ± 481 <0.001
  Missing birth weight, n (%) 1 (0.14) 0 (0) 1 (0.26)
 Birth length (cm) 52.1 ± 2.1 51.7 ± 2.0 52.4 ± 2.0 <0.001
  Missing birth length, n (%) 7 (0.95) 3 (0.85) 4 (1.04)
 Exclusive breastfeeding (weeks) 33 (16;48) 33 (17;50) 34 (15;46) 0.30
  Missing data on breastfeeding, n (%) 152 (20.7) 70 (19.9) 82 (20.4)

*Difference between sexes, tested with independent t-test or Wilcoxon rank sum test for continuous variables and χ2 tests for categorical variables.

FT4, free thyroxine; BMI, body mass index; TPOAb, antibodies against thyroid peroxidase; TSH, thyrotropin.