Table 2.

Association between maternal TPOAb at gestational week median 12 (range: 8–20 weeks) and productive vocabulary from the MacArthur–Bates Communicative Development Inventories (MB-CDI) reports in the offspring aged 12–36 months (models 1 and 2). The association between maternal TPOAb and the probability of producing words from the MB-CDI are estimated by conditional growth models, including effects of time (offspring age) and main effects of covariates. The outputs of the conditional growth models are reported as odds ratios (OR), standard error (SE), and 95% CI. Numbers represent complete cases included in the analyses. P-values <0.05 are significant and marked in bold.

	Girls (n = 277)				Boys (n = 298)
	OR	SE	95% CI	P	OR	SE	95% CI	P
TPOAb (<11.0 vs ≥11.0 kIU/L)
Intercept	1.00	0.00	1.00; 1.00	<0.001	1.00	0.00	1.00; 1.00	<0.001
Offspring age	10.27	6.41×10-3	10.41; 10.40	<0.001	9.79	6.16 × 10−3	9.68; 9.91	<0.001
TPOAb (≥11.0)	0.99	0.09	0.83; 1.18	0.92	1.06	0.09	0.89; 1.27	0.49
Maternal age	0.89	0.10	0.73; 1.07	0.22	0.76	0.10	0.63; 0.92	0.005
Breastfeeding	1.19	0.08	1.02; 1.39	0.03	1.24	0.08	1.05; 1.46	0.01
Maternal education
Linear	1.21	0.09	1.01; 1.44	0.03	1.01	0.09	0.84; 1.21	0.92
Quadratic	1.11	0.09	0.94; 1.31	0.23	0.87	0.09	0.73; 1.02	0.09
Primi- and multi-parous	0.78	0.10	0.64; 0.94	0.009	0.96	0.09	0.80; 1.16	0.68
Pre-pregnancy BMI
<18.5	0.88	0.10	0.72; 1.08	0.22	1.10	0.09	0.92; 1.31	0.29
>25.0	1.04	0.08	0.88; 1.23	0.62	0.96	0.09	0.81; 1.14	0.67
Offspring age × TPOAb (≥11.0)	0.78	0.02	0.75; 0.81	<0.001	0.83	0.02	0.80; 0.86	<0.001
TPOAb (Linear)
Intercept	1.00	0.00	1.00; 1.00	<0.001	1.00	0.00	1.00; 1.00	<0.001
Offspring age	09.97	6.33×10-3	9.84; 10.09	<0.001	9.84	6.43 × 10−3	9.72; 9.96	<0.001
TPOAb (linear)	0.81	0.10	0.67; 0.98	0.03	1.12	0.07	0.97; 1.29	0.61
Maternal age	0.88	0.10	0.73; 1.07	0.21	0.77	0.10	0.64; 0.93	0.005
Breastfeeding	1.19	0.08	1.01; 1.39	0.033	1.23	0.08	1.04; 1.44	0.010
Maternal education
Linear	1.19	0.09	1.00; 1.42	0.05	1.02	0.09	0.85; 1.22	0.97
Quadratic	1.11	0.09	0.93; 1.31	0.24	0.87	0.09	0.73; 1.03	0.09
Primi- and multi-parous	0.78	0.10	0.64; 0.94	0.011	0.95	0.09	0.79; 1.14	0.67
Pre-pregnancy BMI	0.88	0.10	0.72; 1.07	0.19	1.11	0.09	0.93; 1.32	0.30
<18.5
>25.0	1.04	0.09	0.88; 1.23	0.66	0.96	0.09	0.81; 1.14	0.67
Offspring age × TPOAb	1.02	0.02	0.98; 1.06	0.38	0.84	0.02	0.81; 0.87	<0.001

BMI, body mass index; TPOAb, thyroid peroxidase antibodies.