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. Author manuscript; available in PMC: 2024 Jul 6.
Published in final edited form as: Gene Ther. 2022 Dec 12;30(6):478–486. doi: 10.1038/s41434-022-00378-7

Fig. 2. Relocation of the CFTR −35kb enhancer element creates open chromatin at the insertion site in intron 1.

Fig. 2

A Open chromatin mapping of 16HBE14o− WT and 16HBE14o− Δ−35kb cells across the CFTR locus, mapped to the hg19 genome. B Open chromatin mapping of 16HBE14o− Δ−35 kb and ins-35 kb clones, mapped to a modified hg19 genome lacking the sequence removed for the −35 kb deletion (red dotted line) and incorporating the sequence inserted into intron 1 (blue line). C Enlarged regions of panel (B) showing the genomic region surrounding the −35 kb deletion site (left) and −35 kb insertion site (right).