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. 2013 Mar 28;2013(3):CD005028. doi: 10.1002/14651858.CD005028.pub3

Comparison 1. Vitamin D analogues versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 IAGI 20   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.1 Calcipotriol 10 2287 Std. Mean Difference (IV, Random, 95% CI) ‐0.93 [‐1.17, ‐0.68]
1.2 Calcipotriol plus occlusion 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.3 Calcitriol 6 1120 Std. Mean Difference (IV, Random, 95% CI) ‐1.03 [‐1.71, ‐0.36]
1.4 Tacalcitol 2 433 Std. Mean Difference (IV, Random, 95% CI) ‐0.84 [‐1.41, ‐0.26]
1.5 Maxacalcitol 1 103 Std. Mean Difference (IV, Random, 95% CI) ‐1.43 [‐1.91, ‐0.96]
1.6 Paricalcitol OD 1 22 Std. Mean Difference (IV, Random, 95% CI) ‐1.66 [‐2.66, ‐0.67]
1.7 Becocalcidiol OD 1 121 Std. Mean Difference (IV, Random, 95% CI) ‐0.22 [‐0.58, 0.14]
1.8 Becocalcidiol twice daily 1 119 Std. Mean Difference (IV, Random, 95% CI) ‐0.67 [‐1.04, ‐0.30]
2 TSS 19   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
2.1 Calcipotriol 10 1208 Std. Mean Difference (IV, Random, 95% CI) ‐1.15 [‐1.41, ‐0.89]
2.2 Calcipotriol plus occlusion 1 187 Std. Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.44, 0.14]
2.3 Calcitriol 4 1027 Std. Mean Difference (IV, Random, 95% CI) ‐1.22 [‐2.38, ‐0.07]
2.4 Tacalcitol 3 496 Std. Mean Difference (IV, Random, 95% CI) ‐0.66 [‐0.95, ‐0.36]
2.5 Maxacalcitol 1 103 Std. Mean Difference (IV, Random, 95% CI) ‐1.61 [‐2.10, ‐1.12]
2.6 Paricalcitol OD 1 22 Std. Mean Difference (IV, Random, 95% CI) ‐2.15 [‐3.24, ‐1.06]
2.7 Becocalcidiol OD 1 121 Std. Mean Difference (IV, Random, 95% CI) ‐0.02 [‐0.37, 0.34]
2.8 Becocalcidiol twice daily 1 119 Std. Mean Difference (IV, Random, 95% CI) ‐0.46 [‐0.83, ‐0.10]
3 PASI 9 2422 Std. Mean Difference (IV, Random, 95% CI) ‐0.58 [‐0.71, ‐0.45]
3.1 Calcipotriol 8 2195 Std. Mean Difference (IV, Random, 95% CI) ‐0.65 [‐0.75, ‐0.55]
3.2 Calcipotriol plus occlusion 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.3 Calcitriol 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.4 Tacalcitol 1 227 Std. Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.56, 0.03]
3.5 Maxacalcitol 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.6 Paricalcitol OD 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.7 Becocalcidiol OD 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3.8 Becocalcidiol twice daily 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4 PAGI 5 1467 Std. Mean Difference (IV, Random, 95% CI) ‐0.54 [‐0.72, ‐0.36]
4.1 Calcipotriol 2 439 Std. Mean Difference (IV, Random, 95% CI) ‐0.64 [‐0.97, ‐0.30]
4.2 Calcipotriol plus occlusion 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.3 Calcitriol 2 801 Std. Mean Difference (IV, Random, 95% CI) ‐0.59 [‐0.76, ‐0.41]
4.4 Tacalcitol 1 227 Std. Mean Difference (IV, Random, 95% CI) ‐0.24 [‐0.53, 0.05]
4.5 Maxacalcitol 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.6 Paricalcitol OD 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.7 Becocalcidiol OD 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.8 Becocalcidiol twice daily 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Combined end point (IAGI/TSS/PASI/PAGI) 30   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
5.1 Calcipotriol 17 3269 Std. Mean Difference (IV, Random, 95% CI) ‐0.96 [‐1.15, ‐0.77]
5.2 Calcipotriol plus occlusion 1 187 Std. Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.44, 0.14]
5.3 Calcitriol 7 1140 Std. Mean Difference (IV, Random, 95% CI) ‐0.92 [‐1.54, ‐0.29]
5.4 Tacalcitol 4 723 Std. Mean Difference (IV, Random, 95% CI) ‐0.73 [‐1.09, ‐0.37]
5.5 Maxacalcitol 1 103 Std. Mean Difference (IV, Random, 95% CI) ‐1.43 [‐1.91, ‐0.96]
5.6 Paricalcitol OD 1 22 Std. Mean Difference (IV, Random, 95% CI) ‐1.66 [‐2.66, ‐0.67]
5.7 Becocalcidiol OD 1 121 Std. Mean Difference (IV, Random, 95% CI) ‐0.22 [‐0.58, 0.14]
5.8 Becocalcidiol twice daily 1 119 Std. Mean Difference (IV, Random, 95% CI) ‐0.67 [‐1.04, ‐0.30]
6 Total withdrawals 25 4715 Risk Difference (M‐H, Random, 95% CI) ‐0.02 [‐0.05, 0.00]
6.1 Calcipotriol 14 3132 Risk Difference (M‐H, Random, 95% CI) ‐0.03 [‐0.06, 0.00]
6.2 Calcipotriol plus occlusion 0 0 Risk Difference (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6.3 Calcitriol 5 339 Risk Difference (M‐H, Random, 95% CI) ‐0.00 [‐0.02, 0.02]
6.4 Tacalcitol 4 857 Risk Difference (M‐H, Random, 95% CI) ‐0.05 [‐0.14, 0.05]
6.5 Maxacalcitol 1 120 Risk Difference (M‐H, Random, 95% CI) 0.11 [‐0.01, 0.23]
6.6 Paricalcitol OD 1 22 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.16, 0.16]
6.7 Becocalcidiol OD 1 124 Risk Difference (M‐H, Random, 95% CI) ‐0.01 [‐0.12, 0.11]
6.8 Becocalcidiol twice daily 1 121 Risk Difference (M‐H, Random, 95% CI) ‐0.01 [‐0.13, 0.10]
7 Withdrawals due to adverse events 23 4463 Risk Difference (M‐H, Random, 95% CI) ‐0.00 [‐0.02, 0.01]
7.1 Calcipotriol 12 2880 Risk Difference (M‐H, Random, 95% CI) ‐0.02 [‐0.04, 0.00]
7.2 Calcipotriol plus occlusion 0 0 Risk Difference (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7.3 Calcitriol 5 339 Risk Difference (M‐H, Random, 95% CI) ‐0.00 [‐0.02, 0.02]
7.4 Tacalcitol 4 857 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.01, 0.02]
7.5 Maxacalcitol 1 120 Risk Difference (M‐H, Random, 95% CI) ‐0.01 [‐0.08, 0.06]
7.6 Paricalcitol OD 1 22 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.16, 0.16]
7.7 Becocalcidiol OD 1 124 Risk Difference (M‐H, Random, 95% CI) 0.03 [‐0.02, 0.08]
7.8 Becocalcidiol twice daily 1 121 Risk Difference (M‐H, Random, 95% CI) 0.05 [‐0.01, 0.11]
8 Withdrawals due to treatment failure 14 2752 Risk Difference (M‐H, Random, 95% CI) ‐0.03 [‐0.05, 0.00]
8.1 Calcipotriol 7 1770 Risk Difference (M‐H, Random, 95% CI) ‐0.03 [‐0.08, 0.01]
8.2 Calcipotriol plus occlusion 0 0 Risk Difference (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8.3 Calcitriol 4 281 Risk Difference (M‐H, Random, 95% CI) ‐0.03 [‐0.12, 0.05]
8.4 Tacalcitol 1 314 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.01, 0.01]
8.5 Maxacalcitol 1 120 Risk Difference (M‐H, Random, 95% CI) ‐0.03 [‐0.11, 0.04]
8.6 Paricalcitol OD 1 22 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.16, 0.16]
8.7 Becocalcidiol OD 1 124 Risk Difference (M‐H, Random, 95% CI) ‐0.02 [‐0.07, 0.04]
8.8 Becocalcidiol twice daily 1 121 Risk Difference (M‐H, Random, 95% CI) ‐0.03 [‐0.09, 0.02]
9 Adverse events (local) 19 4402 Risk Difference (M‐H, Random, 95% CI) 0.00 [‐0.01, 0.02]
9.1 Calcipotriol 11 2652 Risk Difference (M‐H, Random, 95% CI) 0.01 [‐0.03, 0.05]
9.2 Calcipotriol plus occlusion 0 0 Risk Difference (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9.3 Calcitriol 4 917 Risk Difference (M‐H, Random, 95% CI) ‐0.01 [‐0.03, 0.02]
9.4 Tacalcitol 2 566 Risk Difference (M‐H, Random, 95% CI) ‐0.00 [‐0.03, 0.03]
9.5 Maxacalcitol 0 0 Risk Difference (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9.6 Paricalcitol OD 1 22 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.16, 0.16]
9.7 Becocalcidiol OD 1 124 Risk Difference (M‐H, Random, 95% CI) 0.01 [‐0.06, 0.08]
9.8 Becocalcidiol twice daily 1 121 Risk Difference (M‐H, Random, 95% CI) 0.10 [0.00, 0.19]
10 Adverse events (systemic) 14 2463 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.01, 0.01]
10.1 Calcipotriol 8 1182 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.01, 0.01]
10.2 Calcipotriol plus occlusion 0 0 Risk Difference (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
10.3 Calcitriol 3 647 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.01, 0.01]
10.4 Tacalcitol 1 244 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.02, 0.02]
10.5 Maxacalcitol 1 120 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.05, 0.05]
10.6 Paricalcitol OD 1 22 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.16, 0.16]
10.7 Becocalcidiol OD 1 124 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.03, 0.03]
10.8 Becocalcidiol twice daily 1 124 Risk Difference (M‐H, Random, 95% CI) 0.0 [‐0.03, 0.03]