1 IAGI |
20 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
1.1 Calcipotriol |
10 |
2287 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.93 [‐1.17, ‐0.68] |
1.2 Calcipotriol plus occlusion |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
1.3 Calcitriol |
6 |
1120 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.03 [‐1.71, ‐0.36] |
1.4 Tacalcitol |
2 |
433 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.84 [‐1.41, ‐0.26] |
1.5 Maxacalcitol |
1 |
103 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.43 [‐1.91, ‐0.96] |
1.6 Paricalcitol OD |
1 |
22 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.66 [‐2.66, ‐0.67] |
1.7 Becocalcidiol OD |
1 |
121 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.22 [‐0.58, 0.14] |
1.8 Becocalcidiol twice daily |
1 |
119 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.67 [‐1.04, ‐0.30] |
2 TSS |
19 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
2.1 Calcipotriol |
10 |
1208 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.15 [‐1.41, ‐0.89] |
2.2 Calcipotriol plus occlusion |
1 |
187 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.15 [‐0.44, 0.14] |
2.3 Calcitriol |
4 |
1027 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.22 [‐2.38, ‐0.07] |
2.4 Tacalcitol |
3 |
496 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.66 [‐0.95, ‐0.36] |
2.5 Maxacalcitol |
1 |
103 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.61 [‐2.10, ‐1.12] |
2.6 Paricalcitol OD |
1 |
22 |
Std. Mean Difference (IV, Random, 95% CI) |
‐2.15 [‐3.24, ‐1.06] |
2.7 Becocalcidiol OD |
1 |
121 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.02 [‐0.37, 0.34] |
2.8 Becocalcidiol twice daily |
1 |
119 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.46 [‐0.83, ‐0.10] |
3 PASI |
9 |
2422 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.58 [‐0.71, ‐0.45] |
3.1 Calcipotriol |
8 |
2195 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.65 [‐0.75, ‐0.55] |
3.2 Calcipotriol plus occlusion |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
3.3 Calcitriol |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
3.4 Tacalcitol |
1 |
227 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.27 [‐0.56, 0.03] |
3.5 Maxacalcitol |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
3.6 Paricalcitol OD |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
3.7 Becocalcidiol OD |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
3.8 Becocalcidiol twice daily |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
4 PAGI |
5 |
1467 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.54 [‐0.72, ‐0.36] |
4.1 Calcipotriol |
2 |
439 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.64 [‐0.97, ‐0.30] |
4.2 Calcipotriol plus occlusion |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
4.3 Calcitriol |
2 |
801 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.59 [‐0.76, ‐0.41] |
4.4 Tacalcitol |
1 |
227 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.24 [‐0.53, 0.05] |
4.5 Maxacalcitol |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
4.6 Paricalcitol OD |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
4.7 Becocalcidiol OD |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
4.8 Becocalcidiol twice daily |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
5 Combined end point (IAGI/TSS/PASI/PAGI) |
30 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
5.1 Calcipotriol |
17 |
3269 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.96 [‐1.15, ‐0.77] |
5.2 Calcipotriol plus occlusion |
1 |
187 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.15 [‐0.44, 0.14] |
5.3 Calcitriol |
7 |
1140 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.92 [‐1.54, ‐0.29] |
5.4 Tacalcitol |
4 |
723 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.73 [‐1.09, ‐0.37] |
5.5 Maxacalcitol |
1 |
103 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.43 [‐1.91, ‐0.96] |
5.6 Paricalcitol OD |
1 |
22 |
Std. Mean Difference (IV, Random, 95% CI) |
‐1.66 [‐2.66, ‐0.67] |
5.7 Becocalcidiol OD |
1 |
121 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.22 [‐0.58, 0.14] |
5.8 Becocalcidiol twice daily |
1 |
119 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.67 [‐1.04, ‐0.30] |
6 Total withdrawals |
25 |
4715 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.02 [‐0.05, 0.00] |
6.1 Calcipotriol |
14 |
3132 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.03 [‐0.06, 0.00] |
6.2 Calcipotriol plus occlusion |
0 |
0 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
6.3 Calcitriol |
5 |
339 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.00 [‐0.02, 0.02] |
6.4 Tacalcitol |
4 |
857 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.05 [‐0.14, 0.05] |
6.5 Maxacalcitol |
1 |
120 |
Risk Difference (M‐H, Random, 95% CI) |
0.11 [‐0.01, 0.23] |
6.6 Paricalcitol OD |
1 |
22 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.16, 0.16] |
6.7 Becocalcidiol OD |
1 |
124 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.12, 0.11] |
6.8 Becocalcidiol twice daily |
1 |
121 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.13, 0.10] |
7 Withdrawals due to adverse events |
23 |
4463 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.00 [‐0.02, 0.01] |
7.1 Calcipotriol |
12 |
2880 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.02 [‐0.04, 0.00] |
7.2 Calcipotriol plus occlusion |
0 |
0 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
7.3 Calcitriol |
5 |
339 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.00 [‐0.02, 0.02] |
7.4 Tacalcitol |
4 |
857 |
Risk Difference (M‐H, Random, 95% CI) |
0.00 [‐0.01, 0.02] |
7.5 Maxacalcitol |
1 |
120 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.08, 0.06] |
7.6 Paricalcitol OD |
1 |
22 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.16, 0.16] |
7.7 Becocalcidiol OD |
1 |
124 |
Risk Difference (M‐H, Random, 95% CI) |
0.03 [‐0.02, 0.08] |
7.8 Becocalcidiol twice daily |
1 |
121 |
Risk Difference (M‐H, Random, 95% CI) |
0.05 [‐0.01, 0.11] |
8 Withdrawals due to treatment failure |
14 |
2752 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.03 [‐0.05, 0.00] |
8.1 Calcipotriol |
7 |
1770 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.03 [‐0.08, 0.01] |
8.2 Calcipotriol plus occlusion |
0 |
0 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
8.3 Calcitriol |
4 |
281 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.03 [‐0.12, 0.05] |
8.4 Tacalcitol |
1 |
314 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.01, 0.01] |
8.5 Maxacalcitol |
1 |
120 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.03 [‐0.11, 0.04] |
8.6 Paricalcitol OD |
1 |
22 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.16, 0.16] |
8.7 Becocalcidiol OD |
1 |
124 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.02 [‐0.07, 0.04] |
8.8 Becocalcidiol twice daily |
1 |
121 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.03 [‐0.09, 0.02] |
9 Adverse events (local) |
19 |
4402 |
Risk Difference (M‐H, Random, 95% CI) |
0.00 [‐0.01, 0.02] |
9.1 Calcipotriol |
11 |
2652 |
Risk Difference (M‐H, Random, 95% CI) |
0.01 [‐0.03, 0.05] |
9.2 Calcipotriol plus occlusion |
0 |
0 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
9.3 Calcitriol |
4 |
917 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.03, 0.02] |
9.4 Tacalcitol |
2 |
566 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.00 [‐0.03, 0.03] |
9.5 Maxacalcitol |
0 |
0 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
9.6 Paricalcitol OD |
1 |
22 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.16, 0.16] |
9.7 Becocalcidiol OD |
1 |
124 |
Risk Difference (M‐H, Random, 95% CI) |
0.01 [‐0.06, 0.08] |
9.8 Becocalcidiol twice daily |
1 |
121 |
Risk Difference (M‐H, Random, 95% CI) |
0.10 [0.00, 0.19] |
10 Adverse events (systemic) |
14 |
2463 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.01, 0.01] |
10.1 Calcipotriol |
8 |
1182 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.01, 0.01] |
10.2 Calcipotriol plus occlusion |
0 |
0 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
10.3 Calcitriol |
3 |
647 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.01, 0.01] |
10.4 Tacalcitol |
1 |
244 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.02, 0.02] |
10.5 Maxacalcitol |
1 |
120 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.05, 0.05] |
10.6 Paricalcitol OD |
1 |
22 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.16, 0.16] |
10.7 Becocalcidiol OD |
1 |
124 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.03, 0.03] |
10.8 Becocalcidiol twice daily |
1 |
124 |
Risk Difference (M‐H, Random, 95% CI) |
0.0 [‐0.03, 0.03] |