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. 2013 Mar 28;2013(3):CD005028. doi: 10.1002/14651858.CD005028.pub3

Bruce 1994.

Methods DESIGN 
 Between‐patient
 Participant delivery
 ALLOCATION 
 Random
 Method of randomisation: not reported
 Concealment: unclear
 BLINDING 
 Double‐blind (participant/investigator)
WITHDRAWAL/DROPOUT 
 Described
Participants N: 114
Treatment duration: 6 wks; FU: 6 wks
LF: 15 (13.2%)
BC: yes
Age: 44.1 (14.6SD; range = 20 to 77)
Gender (per cent men): 60.2%
Severity: mean duration of current episode (days) = 142 (range = 0 to 601)
Overall severity score (mean): 4.5
INCLUSION CRITERIA
  • Stable plaque psoriasis

  • Adults

  • At least mild overall severity

  • At least moderately severe plaque elevation


EXCLUSION CRITERIA
  • Pregnancy

  • Lactation

  • Inadequate contraception

  • Sensitivity to test medications

  • Recent topical, UV, or systemic treatment

  • Recent involvement in other trials

  • Planned sun exposure

Interventions
  • Calcipotriol ointment 0.005% BD (C)

  • Fluocinonide ointment 0.05% BD (F)

Outcomes
  1. Sign: scaling, erythema, plaque elevation

  2. Overall severity (Total Sign Score and per cent involvement)

  3. Investigator Global Assessment

Notes Westwood Squibb Pharmaceuticals Inc. sponsored the trial.
 There was SD imputation (TSS).
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk The trial reported insufficient details.
Blinding (performance bias and detection bias) 
 All outcomes Low risk The trial was double‐blind (participant/investigator).
Randomisation method reported Unclear risk The trial did not report this.
Loss to follow up Low risk 13.2%
Baseline assessments Low risk
Baseline comparability demonstrated Low risk