Table 1.
Demographics and clinical characteristics
| Characteristic |
Overall, N = 1001 |
Butler MAP Training Cohort, N = 501 |
Butler MAP Test Cohort, N = 501 |
P-value2 |
|---|---|---|---|---|
| Age | 71 (64, 75) | 69 (65, 75) | 71 (64, 75) | 0.96 |
| Sex, male | 46 (46%) | 20 (40%) | 26 (52%) | 0.32 |
| Race | 0.28 | |||
| White | 77 (97%) | 44 (100%) | 33 (94%) | |
| Black | 1 (1.3%) | 0 (0%) | 1 (2.9%) | |
| Mixed race | 1 (1.3%) | 0 (0%) | 1 (2.9%) | |
| Not reported | 21 | 6 | 15 | |
| Ethnicity | > 0.99 | |||
| Not Hispanic or Latino | 74 (97%) | 42 (98%) | 32 (97%) | |
| Hispanic or Latino | 2 (2.6%) | 1 (2.3%) | 1 (3.0%) | |
| Not reported | 24 | 7 | 17 | |
| APOE-ε43 | 0.86 | |||
| Non-carrier | 25 (28%) | 11 (27%) | 14 (30%) | |
| Heterozygote | 51 (58%) | 25 (61%) | 26 (55%) | |
| Homozygote | 12 (14%) | 5 (12%) | 7 (15%) | |
| Unknown | 12 | 9 | 3 | |
| Clinical diagnosis | < 0.001 | |||
| Cognitively normal | 37 (37%) | 37 (74%) | 0 (0%) | |
| Mild cognitive impairment | 36 (36%) | 7 (14%) | 29 (58%) | |
| Dementia | 27 (27%) | 6 (12%) | 21 (42%) | |
| MMSE, score | 27 (25, 29) | 28 (26, 29) | 27 (24, 28) | 0.013 |
| MoCA, score | 23 (19, 25) | 25 (22, 27) | 22 (18, 23) | < 0.001 |
| Aβ positivity | 70 (70%) | 32 (64%) | 38 (76%) | 0.28 |
1 Median (IQR); n (%)
2 Wilcoxon rank sum test; Pearson's Chi-squared test