Table 2.
Descriptive features of human studies highlighting the gene symbols and gene regions where differential DNA methylation was observed as well as definitions of hearing loss used for each study
| Human studies | ||||
|---|---|---|---|---|
| Author/year | All genes | Hearing loss genes | DNA methylation regions | Hearing loss phenotype |
| Bouzid, A., et al. 2022 | TNFSF11 | PromoterChr13:4257390442574865 | Unspecified | |
| Bouzid, A., et al. 2018 | CDH23 | CDH23 | CpG island site of the junction exon 54intron 54 in CDH2 | Hearing loss thresholds ≥ 20 dB |
| Bouzid, A., et al. 2018 | 227 GENES IN TOTAL REPORTED | ASTN2 | Exon1 Chr9:119449474-119449519 | Hearing loss defined by pure tone audiometry at 0.25 0.5 1 2 4 and 8 kHz frequencies |
| ATP2B3 | Promoter ChrX:152801006-152801151 | |||
| BTBD2 | Exon1 Chr19:2015326-2015433 | |||
| C19orf55 | Promoter Chr19:36247138-36247267 | |||
| CCDC85C | Exon1 Chr14:10006965-100070237 | |||
| CEACAM1 | Promoter Chr19:43034432-43034565 | |||
| ERBB3 | Exon2 Chr19:677925-677973 | |||
| FSTL3 | Exon1 Chr5:75699163-75699285 | |||
| IQGAP2 | Exon1 Chr6:73332056-73332153 | |||
| KCNQ5 | Exon1 Chr17:4458422-4458556 | |||
| MYBBP1A | Exon1 Chr17:7311711-3711829 | |||
| NLGN2 | Promoter Chr12:133195302-13319539 | |||
| P2RX2 | Exon1 Chr12:133195405-133195423 | |||
| PGP | Exon2 Chr16:2261684-2262961 | |||
| RAB2B | Promoter Chr14:21945595-2196532 | |||
| RUSC1 | Exon1 Chr1:155293868-155294305 | |||
| SOCS3 | Exon1_2Chr17:76355149-76355243 | |||
| TMED7-TICAM2 | Exon1 Chr5:114961500-114961615 | |||
| Brown, A. L., et al. 2017 | PAK4 | Chr19: cg14010619 |
Hearing loss defined by pure tone audiometry Grade 0 = < 20 dB Grade 1 = > 20 dB at ≥ 6 kHz Grade2 = > 20 dB at ≥ 4 kHz Grade 3 = > 20 dB at ≥ 2 kHz Grade 4 = > 40 dB at ≥ 2 kHz |
|
| Flook, M., et al. 2021 |
H3Y1 ACSBG1 IL32 |
Meniere Disease | ||
| Guo, L., et al. 2023 | C3 | chr19:6710806-6711077 | Speech-Pure Tone Audiometry of ≥ 25 dB in the better ear was used to define hearing loss | |
| TEX19 | chr17:80303573-80303880 | |||
| GBX2 | chr2:237071725-237072438 | |||
| CD247 | chr1:167408553-167408867 | |||
| SPATA18 | chr4:52942852-52943232 | |||
| ZCCHC8 | chr12:122983976-122984305 | |||
| CD247 | chr1:167408553-167408867 | |||
| TEX19 | chr17:80303573-80303880 | |||
| C3 | chr19:6710806-6711077 | |||
| MRGPRG-AS1 | chr11:3243153-3243455 | |||
| MKX | chr10:28034352-28034507 | |||
| TMEM1 02 | chr17:7339626-7340311 | |||
| SPATA18 | chr4:52942852-52943232 | |||
| GRIN3B | chr19:1008897-1009874 | |||
| LINC02249 | chr15:30517467-30517618 | |||
| PRDM16 | chr1:2990062-2990407 | |||
| OSR2 | chr8:99986099-99986645 | |||
| S100A13 | chr1:153606037-153606314 | |||
| RBMS2 | chr12:56882420-56882571 | |||
| ALG10 | chr12:34499106-34501260 | |||
| GPC5 | chr13:92051618-92051955 | |||
| NRN1 | chr6:6002421-6002736 | |||
| C21orf58 | chr21:47737945-47738279 | |||
| CD247 | ||||
| Hao, J., et al. 2018 | KCNJ11 | Not specified |
Frequency range of 0.7 k–6 kHz for DPOAE Grade 0 = DPOAE meets SNR criteria normal range Grade 1 = DPOAE meets SNR criteria abnormal range Grade 2 = DPOAE does not meet SNR criteria |
|
| Kuo, P. L., et al. 2021 | N/A | N/A | N/A |
Pure tone audiometry 0.5– kHz Higher Pure Tone Audiometry = worse hearing |
| Lassaletta, L., et al. 2006 |
RASSF1A RARB VHL PTEN HMLH1 RB1 ER TP16 CASP8 TIMP3 MGMT DAPK TP73 GSTP1 TP14 THBS |
Not specified | Pure Tone Average threshold of 25db – 62 dB recorded in all patients who displayed hearing loss symptoms | |
| Wolber, L. E., et al. 2014 |
TCF25 PGM3 CDO1 NOC2L MYBPC3 FGFR1 POLE VPS2B HNRNPA APOCC4 |
Not specified | Hearing loss defined by pure tone average for frequencies 0.125–8 kHz according to the recommendations of the British Society of Audiology | |
| Xu, J., et al. 2017 | SLC26A4 | SLC26A4 | Chr7:107300940107301001 | Pure Tone Average greater than 60 dB hearing loss, control less than 26 dB |
| Xu, L., et al. 2020 |
Rb1 CASP8 MeCP2 |
chr13:48877561- 48877684 chr2:202097129- 202122658 chrX:153363708- 154097766 |
Pure Tone Average threshold above 25 dB considered as hearing loss | |