Table 3.

Associations of continues increase of MPA, VPA, and MVPA with Mortality among different MSA frequency group

	Unadjusted model		Multivariable model 1†		Multivariable model 2‡
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
All-cause mortality
MSA < 2 sessions/week
MPA (per 1 h increase)	0.63 (0.47–0.85)	< 0.01	0.65 (0.49–0.87)	< 0.01	0.67 (0.51–0.88)	< 0.01
VPA (per 1 h increase)	0.31 (0.15–0.63)	< 0.01	0.34 (0.17–0.69)	< 0.01	0.38 (0.19–0.77)	< 0.01
MVPA (per 1 h increase)	0.76 (0.66–0.87)	< 0.01	0.77 (0.67–0.89)	< 0.01	0.79 (0.69–0.90)	< 0.01
MSA ≥ 2 sessions/week
MPA (per 1 h increase)	0.65 (0.31–1.34)	< 0.26	0.46 (0.20–1.04)	0.06	0.45 (0.20–0.97)	0.04
VPA (per 1 h increase)	0.02 (0.00-0.25)	< 0.01	0.01 (0.00-0.28)	< 0.01	0.04 (0.00-0.77)	0.03
MVPA (per 1 h increase)	0.63 (0.44–0.92)	0.02	0.53 (0.35–0.79)	< 0.01	0.59 (0.40–0.88)	< 0.01
Cancer mortality
MSA < 2 sessions/week
MPA (per 1 h increase)	0.74 (0.54–1.01)	0.06	0.76 (0.56–1.03)	0.08	0.77 (0.58–1.02)	0.07
VPA (per 1 h increase)	0.29 (0.12–0.73)	< 0.01	0.29 (0.12–0.74)	< 0.01	0.32 (0.13–0.80)	0.01
MVPA (per 1 h increase)	0.81 (0.70–0.95)	< 0.01	0.83 (0.71–0.96)	0.01	0.84 (0.72–0.97)	0.02
MSA ≥ 2 sessions/week
MPA (per 1 h increase)	0.62 (0.23–1.67)	0.35	0.50 (0.16–1.54)	0.23	0.85 (0.30–2.37)	0.75
VPA (per 1 h increase)	0.03 (0.00-0.55)	0.02	0.04 (0.00-0.80)	0.04	0.05 (0.00-1.79)	0.10
MVPA (per 1 h increase)	0.63 (0.39–1.01)	0.06	0.57 (0.34–0.97)	0.04	0.79 (0.47–1.33)	0.37

^†Adjusted for age, sex, race, and marital status

^‡Additionally adjusted for smoking, drinking, diabetes, hypertension, coronary heart disease, stroke, BMI, number of diagnosed cancers, and functional limitation

Abbreviation: MPA, moderate physical activity; VPA, vigorous physical activity; MVPA, moderate to vigorous physical activity; MSA, muscle-strengthening activity; HR, hazard ratio; CI, confidence interval