Table 2.
Predictors of Receipt of Fecal Microbiota Transplantation in Clostridioides difficile Infection Episodes Among Patients With ≥1 Recurrence and Hospitalization
| Predictor | Patients by Receipt of FMT After CDI Episode, No. (%) | OR (95% CI) | |
|---|---|---|---|
| No FMT (n = 3902) | FMT Received (n = 150) | ||
| Demographic characteristics | |||
| Race | |||
| White | 1737 (45) | 90 (60) | Reference |
| Black | 1444 (37) | 34 (23) | 0.19 (.08–.46) |
| Other | 52 (1.3) | 3 (2) | 1.25 (.09–18.60) |
| Unknown | 669 (17) | 23 (15) | 0.42 (.15–1.19) |
| Sex | |||
| Female | 2292 (59) | 109 (72) | Reference |
| Male | 1610 (41) | 41 (27) | 0.55 (.39–.78) |
| Age category | |||
| 18–44 y | 641 (16) | 37 (25) | Reference |
| 45–64 y | 1258 (33) | 50 (33) | 0.40 (.16–1.02) |
| 65–79 y | 1272 (33) | 37 (25) | 0.22 (.08–.60) |
| ≥80 y | 721 (18) | 26 (17) | 0.35 (.11–1.07) |
| Comorbid conditions | |||
| Peripheral vascular disease | 488 (13) | 13 (9) | 0.67 (.38–1.17) |
| Cerebrovascular disease | 703 (18) | 11 (7) | 0.35 (.19–.65) |
| Dementia | 531 (14) | 12 (8) | 0.56 (.31–1.00) |
| Chronic pulmonary disease | 1106 (28) | 41 (27) | 0.98 (.69–1.39) |
| Congestive heart failure | 1739 (45) | 44 (29) | 0.55 (.39–.77) |
| Rheumatoid disease | 220 (6) | 10 (7) | 1.24 (.68–2.26) |
| Peptic ulcer disease | 336 (8.6) | 10 (7) | 0.77 (.41–1.44) |
| Mild liver disease | 487 (12) | 10 (7) | 0.51 (.27–.97) |
| Diabetes | 1363 (35) | 34 (23) | 0.54 (.37–.79) |
| Diabetes with complications | 1229 (32) | 23 (15) | 0.41 (.27–.64) |
| Hemiplegia or paraplegia | 283 (7) | 6 (4) | 0.53 (.23–1.19) |
| Renal disease | 1749 (45) | 37 (25) | 0.42 (.29–.6) |
| Cancer | 698 (18) | 21 (14) | 0.78 (.50–1.22) |
| Moderate to severe liver disease | 165 (4.2) | 1 (0.7) | 0.14 (.02–1.0) |
| HIV | 163 (4) | 4 (3) | 0.75 (.31–1.78) |
| Inflammatory bowel disease | 48 (1) | 1 (0.01) | 0.52 (.03–2.5) |
| Dialysis | 318 (4) | 6 (4) | 0.47 (.18–.98) |
| CDI episode | |||
| 2 | 2442 (63) | 53 (35) | Reference |
| 3 | 806 (21) | 55 (37) | 13.9 (5.66–34.14) |
| 4 | 326 (8) | 30 (20) | 26.7 (9.06–78.81) |
| 5 | 156 (4) | 5 (3) | 2.25 (.24–20.65) |
| >5 | 172 (4) | 7 (5) | 3.32 (.50–22.00) |
Abbreviations: CDI, Clostridioides difficile infection; CI, confidence interval; FMT, fecal microbiota transplantation; HIV, human immunodeficiency virus; OR, odds ratio.