Table 3.
The changed in biochemical data during the supplementation period
| Variables | Groups (number) | Δ8th week | Δ20th week | Δ36th week | Δ44th week | ΔE-12th week | ΔE-24th week |
|---|---|---|---|---|---|---|---|
| WBC (103/uL) | control (n = 7) | 0.2 ± 2.59 | 0.67 ± 4.04 | - | - | - | - |
| fucoidan (n = 13) | 0 ± 2.31 | 1 ± 2 | 1 ± 2.64 | –1 ± 2.83 | –2.5 ± 4.9 | 7 ± 5.66 | |
| Albumin | control (n = 7) | 0 ± 0.71 | –0.33 ± 0.58 | - | - | - | - |
| fucoidan (n = 13) | 0.29 ± 0.49 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | –0.5 ± 0.71 | |
| Pre-albumin | control (n = 7) | –0.86 ± 6.81 | –11.05 ± 4.03 | - | - | - | - |
| fucoidan (n = 13) | 3.19 ± 8.98 | –0.28 ± 8.05 | –3.05 ± 3.46 | - | –2.65 ± 2.33 | 6.95 ± 4.03 | |
| Transferrin | control (n = 7) | 23.12 ± 88.39 | –34 ± 41.79 | - | - | - | - |
| fucoidan (n = 13) | 29.92 ± 30.15 | 9 ± 7.45 | - | - | - | - | |
| T-Protein | control (n = 7) | –0.6 ± 1.14 | 1 ± 1 | - | - | - | - |
| fucoidan (n = 13) | 0.29 ± 0.48 | 0.33 ± 0.51 | 0.5 ± 0.71 | 0 ± 1.41 | 0.5 ± 0.71 | 0 ± 1.41 | |
| GOT (U/L) | control (n = 7) | 3.6 ± 8.73 | 5.33 ± 13.05 | - | - | - | - |
| fucoidan (n = 13) | –1.86 ± 9.74 | –4.67 ± 10.5 | –4.33 ± 13.86 | –7.5 ± 9.19 | 17 ± 21.92 | –4.5 ± 2.12 | |
| GPT (U/L) | control (n = 7) | 4.6 ± 8.65 | 4 ± 8.18 | - | - | - | - |
| fucoidan (n = 13) | 1.57 ± 17.71 | –2.7 ± 11.83 | –5.67 ± 7.76 | –7.5 ± 2.12 | 6 ± 18.38 | –5 ± 9.89 | |
| BUN (mg/dl) | control (n = 7) | –5 ± 2.5 | –4.67 ± 6.65 | - | - | - | - |
| fucoidan (n = 13) | 2 ± 5.47 | 3.67 ± 6.5 | –1.67 ± 2.08 | 2.5 ± 7.77 | –1.5 ± 0.7 | - | |
| Creatinine (mg/dl) | control (n = 7) | –0.04 ± 0.16 | –0.08 ± 0.235 | - | - | - | - |
| fucoidan (n = 13) | 0.06 ± 0.08 | 0 ± 0.13 | 0.053 ± 0.098 | –0.01 ± 0.16 | –0.02 ± 0.233 | –O.U ± 2.32 | |
| TG (mg/dl) | control (n = 7) | - | - | - | - | - | - |
| fucoidan (n = 13) | - | –8.4 ± 94.13 | –89.25 ± 80 | - | –82.5 ± 136.47 | –95.5 ± 147.78 | |
| Choloesterol(mg/dl) | control (n = 7) | - | - | 61 ± 79. 19 | - | - | - |
| fucoidan (n = 13) | - | –8.8 ± 20.6 | –9.5 ± 13.43 | - | - | –12.5 ± 57.27 |
WBC = White blood cell; NLR = neutrophil-to-lymphocyte ratio; GOT = aspartate aminotransferase; GPT = alanine aminotransferase; BUN = blood urea nitrogen; TG = Triglyceride; E = during follow period.
∆: The changed concentrations of cytokines (supplementation week – 0 week).