Kandil 2014.
Methods | Randomized controlled trial. | |
Participants | 100 primigravid women with singleton pregnancy at term undergoing elective cesarean. Excluded: age < 20 or > 30 years; BMI < 19 or >= 25; exposure to antibiotics within 1 week of delivery; premature rupture of membranes; indication for emergency cesarean; hypersensitivity to cephalosporins; temperature > 37.8 degrees celsius. |
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Interventions | 2 g cefazolin administered 30 minutes preoperatively (n = 50) versus after cord clamp (n = 50). | |
Outcomes | Endometritis, wound infection, UTI. | |
Notes | 1 hospital in Egypt. June 2011‐December 2012. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | 50 cards were prepared for each intervention. The cards were placed into opaque envelopes and "shuffled to produce a form of random assignment". |
Allocation concealment (selection bias) | Low risk | Sequentially numbered opaque envelopes. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | This was not specified, but we suspect that no blinding occurred. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | This was not specified, but we suspect that no blinding occurred. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | None reported. |
Selective reporting (reporting bias) | Low risk | Prespecified outcomes stated. |
Other bias | Low risk | No other bias evident. |