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. 2014 Dec 5;2014(12):CD009516. doi: 10.1002/14651858.CD009516.pub2

Witt 2011.

Methods Randomized controlled trial.
Participants 1112 women with a fetus ≥ 37 weeks' gestation undergoing elective cesarean delivery of a fetus with reassuring fetal heart rate tracing.
Interventions Group A: 2 g cefazolin in 100 mL saline 20‐30 minutes before incision (n = 370).
Group B: 2 g cefazolin in 100 mL saline immediately after cord clamp (n = 371).
Group C: 100 mL saline 20‐30 minutes before incision (n = 371).
Outcomes Total postoperative infectious morbidity (endometritis, wound infection, UTI).
Notes 1 hospital in Vienna, Austria. 3/1/04 ‐ 1/31/10.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated permuted blocks of 5.
Allocation concealment (selection bias) Low risk Only the study nurse was not blinded and handed appropriate infusion bag to anesthesiologist.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Women and surgeons masked to administration schedule.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Infectious morbidity was evaluated by 2 residents who were masked to group assignments.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Protocol violations in Groups 1, 2, and 3 respectively: 12, 7, and 13. 32 women lost to follow‐ up/protocol violations/withdrawal.
Selective reporting (reporting bias) Low risk Prespecified outcomes.
Other bias Low risk No other bias evident.