Witt 2011.
Methods | Randomized controlled trial. | |
Participants | 1112 women with a fetus ≥ 37 weeks' gestation undergoing elective cesarean delivery of a fetus with reassuring fetal heart rate tracing. | |
Interventions | Group A: 2 g cefazolin in 100 mL saline 20‐30 minutes before incision (n = 370). Group B: 2 g cefazolin in 100 mL saline immediately after cord clamp (n = 371). Group C: 100 mL saline 20‐30 minutes before incision (n = 371). |
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Outcomes | Total postoperative infectious morbidity (endometritis, wound infection, UTI). | |
Notes | 1 hospital in Vienna, Austria. 3/1/04 ‐ 1/31/10. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated permuted blocks of 5. |
Allocation concealment (selection bias) | Low risk | Only the study nurse was not blinded and handed appropriate infusion bag to anesthesiologist. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Women and surgeons masked to administration schedule. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Infectious morbidity was evaluated by 2 residents who were masked to group assignments. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Protocol violations in Groups 1, 2, and 3 respectively: 12, 7, and 13. 32 women lost to follow‐ up/protocol violations/withdrawal. |
Selective reporting (reporting bias) | Low risk | Prespecified outcomes. |
Other bias | Low risk | No other bias evident. |