FIGURE 1.

Opposing old dogmas and new insights on liver macrophage biology and therapeutic approaches. Determining shifts in our understanding of macrophage biology led to a long-needed redefinition of the liver macrophage landscape. In particular, the field evolved from considering liver macrophages as a homogeneous pool of phagocytes to recognizing their extended diversity in origins and fate and functions in homeostasis and disease. This results in a paradigm shift from immunosuppressive to immunomodulating therapeutic approaches.