FIGURE 2.

Multidimensional dissection of liver macrophages. Recent insights into liver macrophage diversity drastically expanded the number of dimensions in which those highly versatile immune cells may be characterized. Beyond classical and alternative phenotype hallmarks, liver macrophages may now be defined in situ, in vitro, and even in silico through additional metadata such as their morphological peculiarities, functional assets, neighboring, and interactome, among other traits. Technological advances (hardware and software) growing at an unprecedented pace allow for this accelerating expansion of the liver macrophage universe.