TABLE 2.

Predictors of FIB4 slope (per 0.01 slope unit)

	Simple			Multivariable
	b	SE	p	b	SE	p
(Intercept)	3.84	0.04	<0.0001	−0.65	0.25	0.01
Baseline FIB4 per 0.1 increase	0.10	0.01	<0.0001	0.03	0.01	<0.0001
Age at entry, per year	0.11	0.00	<0.0001	0.09	0.00	<0.0001
Sex
Female	Reference
Male	1.05	0.08	<0.0001	0.45	0.09	<0.0001
Genetic ancestry
European	Reference
African	−0.82	0.07	<0.0001	−0.48	0.07	<0.0001
Hispanic	−0.29	0.09	0.0016	−0.04	0.09	0.81
BMI class
Ideal	Reference
Underweight	−0.07	0.35	0.83	0.01	0.35	0.88
Overweight	−0.77	0.14	<0.0001	−0.73	0.14	<0.0001
Class 1 obesity	−1.04	0.15	<0.0001	−0.99	0.15	<0.0001
Class 2 obesity	−0.83	0.14	<0.0001	−0.78	0.14	<0.0001
Class 3 obesity	−0.60	0.15	0.0001	−0.50	0.15	0.0008
Tobacco use
Nonsmoker	Reference
Former	0.12	0.38	0.03	−0.06	0.06	0.32
Current	0.03	0.05	0.67	0.08	0.07	0.25
Diabetes mellitus
Absent	Reference
Present	0.91	0.06	<0.0001	0.58	0.06	<0.0001
Baseline use of metformin
Absent	Reference
Present	−0.02	0.07	0.78	−0.49	0.07	<0.0001
Baseline use of insulin
Absent	Reference
Present	0.85	0.09	<0.0001	0.64	0.10	<0.0001
Baseline use of sulfonylurea
Absent	Reference
Present	0.25	0.08	0.0015	0.03	0.09	0.7696
Baseline use of thiazolidinedione
Absent	Reference
Present	0.68	0.21	0.0012	0.39	0.22	0.07
Baseline use of SGLT2i
Absent	Reference
Present	−1.13	0.78	0.14	−1.15	0.81	0.16
Baseline use of GLP1RA
Absent	Reference
Present	−0.68	0.54	0.20	−1.10	0.56	0.048
Baseline use of statin
Absent	Reference
Present	0.27	0.05	<0.0001	−0.14	0.05	0.0092
Baseline use of fibrate
Absent	Reference
Present	0.80	0.11	<0.0001	0.66	0.11	<0.0001

Abbreviation: FIB4, Fibrosis-4.