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. 2024 Jul 5;8(7):e0478. doi: 10.1097/HC9.0000000000000478

FIGURE 2.

FIGURE 2

Elevated serum-conjugated, especially taurine-conjugated bile acids in HCVi and associated with liver disease severity. (A) Bar plots showing the percentage distribution of BA groups. Circulatory compartment and HCV status on x axis (HCVi, n = 29; SVR, n = 23). In HCVi compared to SVR, portal and peripheral serum had (B) higher total BA (TBA) pool, that is, sum of 24 measured serum BA (C) higher conjugated but not free BA, example of Taurine-BA (D) higher ratios of Tau-BA to Gly-BA (T/G BA ratio), primary to secondary BA, and higher atypical triple-hydroxylated BA, that is, TBMCA and GHC. Two-sided Wilcoxon matched-pairs signed rank test (HCVi vs. SVR, n = 22). Column bar graph, median with IQR. FDRp value + =0.05–0.1, *0.05–0.01, **0.01–0.001, ***0.001–0.0001, ****< 0.0001. (E) Only conjugated, not free BA correlated with liver disease severity markers in HCVi (n = 29). Heatmap with two-sided Spearman correlation. unadjusted p value + =0.05–0.1, *0.05–0.01, **0.01–0.001, ***< 0.001. Abbreviations: BA, bile acid; GHC, glycohycholate; HCVi, patients infected with HCV; SVR, sustained virologic response; TBA, total bile acid; TBMCA, tauro-beta-muricholate.