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. 2024 Jul 5;8(7):e0478. doi: 10.1097/HC9.0000000000000478

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Reduced hepatic bile acid synthesis with enhanced peripheral spillover in HCVi. (A) Hepatic “Bile Secretion” pathway visualized using PathView R package. Gene set enrichment using GAGE R and KEGG pathways database on differentially expressed genes (FDRp < 0.1) from DeSeq2, highlighted blue for fold-change >0 and red for fold-change <0 in HCVi versus SVR (n = 22). (B) Decreased hepatic BA synthesis genes CYP7A1 and CYP7B1, and BA conjugation genes BAAT and SLC27A5/BACS. Two-sided Wilcoxon matched-pairs signed rank test (n = 22). Column bar graph, median with IQR. FDRp value + =0.05–0.1, *0.05–0.01, **0.01–0.001, ***0.001–0.0001, ****< 0.0001. Abbreviations: BA, bile acid; FDR, false discovery rate; HCVi, patients infected with HCV; KEGG, Kyoto Encyclopedia of Genes and Genomes.