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. 2024 Jul 5;8(7):e0478. doi: 10.1097/HC9.0000000000000478

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graphic file with name hc9-8-e0478-g005.jpg — Re-evaluation after SVR revealed the importance of splenic bile acids in cirrhosis independent of HCV. Graphic visualization of primary BA (Metabolon Pathway Explorer) comparing SVR-Cirr versus SVR-NC in (A) portal, (B) peripheral, and (C) splenic serum. Node and node size represent primary BA and fold-change, respectively, colored red for unadjusted p < 0.05, one-way ANOVA. For peripheral/portal BA, SVR-Cirr, n = 9; SVR-NC, n = 14; for splenic BA, SVR-Cirr, n = 8 and SVR-NC, n = 12. (D) In SVR, macrophage activation markers sCD163, IL6, and peptidoglycan showed the strongest association with splenic Tau-BA. Scatter plot, Spearman rank correlation (n = 20). Abbreviations: BA, bile acid; SVR, sustained virologic response; SVR-Cirr, SVR cirrhotics; SVR-NC, SVR non-cirrhotics.

graphic file with name hc9-8-e0478-g006.jpg — Re-evaluation after SVR revealed the importance of splenic bile acids in cirrhosis independent of HCV. Graphic visualization of primary BA (Metabolon Pathway Explorer) comparing SVR-Cirr versus SVR-NC in (A) portal, (B) peripheral, and (C) splenic serum. Node and node size represent primary BA and fold-change, respectively, colored red for unadjusted p < 0.05, one-way ANOVA. For peripheral/portal BA, SVR-Cirr, n = 9; SVR-NC, n = 14; for splenic BA, SVR-Cirr, n = 8 and SVR-NC, n = 12. (D) In SVR, macrophage activation markers sCD163, IL6, and peptidoglycan showed the strongest association with splenic Tau-BA. Scatter plot, Spearman rank correlation (n = 20). Abbreviations: BA, bile acid; SVR, sustained virologic response; SVR-Cirr, SVR cirrhotics; SVR-NC, SVR non-cirrhotics.