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. 2024 Jul 5;8(7):e0478. doi: 10.1097/HC9.0000000000000478

FIGURE 5.

FIGURE 5

Hepatic bile acid receptors, especially S1PR2, strongly linked to conjugated BA and liver disease severity in HCVi. (A) Correlation heatmap of serum BA subgroups (y axis) with mRNA expression of hepatic G-protein–coupled BA receptors (GPCR) in HCVi (n = 27). Two-sided Spearman correlation. Unadjusted p value + =0.05–0.1, *0.05–0.01, **0.01–0.001, ***<0.0001. (B) Among hepatic GPCR, only S1PR2 and FPR1 showed enhanced expression in HCVi. Two-sided Wilcoxon matched-pairs signed rank test. HCVi versus SVR (n = 22). Column bar graph, median with IQR. FDRp value + =0.05–0.1, *0.05–0.01, **0.01–0.001, ***0.001–0.0001, ****< 0.0001. (C) Only S1PR2 showed elevated hepatic expression in HCVi-Cirr; 2-sided Mann-Whitney U test, HCVi-Cirr (n = 13) versus HCVi-NC (n = 16), interleaved scatter with bars graph, median with IQR, unadjusted p value + =0.05–0.1, *0.05–0.01, **0.01–0.001, ***0.001–0.0001, ****< 0.0001, and (D) among hepatic GPCR (x axis), S1PR2 correlated with liver disease severity markers (y axis). Same parameters as panel A. Abbreviations: BA, bile acid; GPCR, G-protein–coupled receptor; HCVi, patients infected with HCV; HCV-Cirr, HCVi cirrhotics; HCVi-NC, HCVi non-cirrhotics; S1PR2, spingosine-1-phosphate receptor 2.