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. Author manuscript; available in PMC: 2024 Jul 6.
Published in final edited form as: Cell. 2023 Oct 16;186(22):4851–4867.e20. doi: 10.1016/j.cell.2023.09.013

Figure 1. Serotonin deficiency in PASC.

Figure 1.

(A and B) Study schematic (A) and differential abundance ranking (B) of metabolomics data from COVID-19 patients vs. healthy controls.

(C and D) Study schematic (C) and uniform manifold approximation and projection (UMAP) clusters (D) of symptom presentation in UPenn PASC cohort.

(E and F) Symptom distribution in PASC cohort clusters.

(G–J) Study schematic (G), principal component analysis (PCA) plot and PC1 values from targeted metabolomics data (H), heatmap of metabolites decreasing in acute COVID-19 and not recovering in PASC (I), and plasma serotonin (J) in acute COVID-19, recovered, and PASC patients.

Plotted are means ± SEM. **p < 0.01, ****p < 0.0001. See also Figures S1 and S2.