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. 2024 Jul 6;14:15564. doi: 10.1038/s41598-024-66482-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LILRB4 knockdown promotes contractile phenotype switching and ECM stabilization in AD cell models. (A) The mRNA level of LILRB4 in the control, PDGF-BB, PDGF-BB + siNC, PDGF-BB + si-LILRB4-1, and PDGF-BB + si-LILRB4-2 groups was detected by RT-qPCR. The data are expressed as mean ± standard deviation (SD) from three biological replicates. One way ANOVA followed by Tukey’s post-hoc test: ^**P < 0.01 vs. Control group, ^##P < 0.01 versus PDGF-BB + si-NC group. (B) Western blot analysis was conducted to assess the levels of contractile proteins, including α-SMA and SM22α, synthetic proteins S100A4, as well as ECM-related proteins LOX, MMP2, and MMP9 in the control, PDGF-BB, PDGF-BB + si-NC, and PDGF-BB + si-LILRB4 groups. Data are represented as mean ± standard deviation (SD) of three independent experiments. One way ANOVA followed by Tukey’s post-hoc test: ^**P < 0.01 versus Control group; Unpaired Student's t test: ^##P < 0.01 versus PDGF-BB + si-NC group.