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. 2024 Jul 6;14:15564. doi: 10.1038/s41598-024-66482-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of JAK/STAT signaling pathway on PDGF-BB-induced HASMC function. (A) The CCK-8 assay was used to investigate the effect of the JAK2/STAT3 signaling pathway inhibitor AG490 on PDGF-BB-induced HASMC viability. (B) The impact of on migration was assessed using the wound healing assay. (C–D) Flow cytometry was employed to evaluate apoptosis and cell cycle distribution after AG490 treatment. The data are expressed as mean ± standard deviation (SD) of three biological replicates. Unpaired Student's t test: ^**P < 0.01 versus Control group; ^##P < 0.01 versus PDGF-BB group.