Table 1.

Risk stratification in HPV-OPSCC

Risk level	Pathologic features
Low risk	Negative margins (>3 mm), N0–N1,no ENE
Intermediate risk	Close margins (< 3 mm), 2–4 positive nodes, ≤ 1 mm ENE, PNI/LVI
High risk	Positive margin, > 1 mm ENE, ≥ 5 positive nodes

Abbreviations: ENE, extranodal extension; HPV, human papillomavirus; LVI, lymphovascular invasion; N, node (value indicates degree of nodal spread); OPSCC, oropharyngeal squamous cell carcinoma; PNI, perineural invasion.