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. 2024 Jul 6;15:199. doi: 10.1186/s13287-024-03817-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — m-NG2/_BMMSCs homed to lesions, differentiated into BDCs and promoted host BDC-mediated hepatocyte regeneration as a core component of m-_BMMSC functions. (A) CFSE-labeled m-NG2/_BMMSCs and m-_BMMSCs migrated into injured areas of the liver 72 h after transplantation. (B) Quantitative analysis of the data in A (boxes, n = 6). (Ca-c) IF staining of CK19⁺ cells (red) differentiated from CFSE-labeled m-NG2/_BMMSCs (a) and m-_BMMSCs (b) and quantification (c, merged, n = 6, the. The boxes represent CK19⁺ cells that formed vessel-like structures). (Da-c) Double IF staining of host CK19⁺ cells (green, arrows) after 72 h covered by ALB⁺ cells (red) in mice (livers) treated with m-NG2/_BMMSCs (a) or m-_BMMSCs (b) and quantification of the merged cells (arrows, c, n = 6). (Ea-c) Analysis of CK7 by IF staining (red) (a, b) and mRNA levels using RT‒qPCR (c); n = 6. (Fa-c) Similar analysis to E for CK19, n = 6. The data are presented as the means ± SDs from several independent experiments. Scale bar = 200 μm. **P < 0.001 compared with m-_BMMSCs; ns represents no significant difference