Figure 1.

Schematic of Stasys platelet system. (A) Schematic of analyzer cartridge in which whole blood is injected at the inlet and flows across (B) arrays of microscale blocks and flexible posts for the measurement of platelet forces. (C) Simulation of shear forces created by microfluidics, including the high shear that platelets encounter as they flow over the blocks and posts. (D) Scanning electron microscopy micrograph of a platelet aggregate formed on a block and post after 45 seconds at 8000 s−1 shear force. Platelets have undergone shear-induced activation and shape change. Platelet contractile force is derived from the change in distance between the block and post over time as the platelet aggregate contracts and pulls the post upstream toward the block. Scale bar, 10 μm. Adapted from Ting et al.⁹ Copyright 2019 by the author(s): http://creativecommons.org/licenses/by/4.0/.