Table 2.

Activities of compound 8 against 27 clinical isolated H. pylori strains (MIC, μg/mL)

^aCLA: MIC breakpoint of CLA for H. pylori: ≤0.25 μg/mL for susceptible, and >0.25 μg/mL for resistant, according to EUCAST

^bMTZ: MIC breakpoint of MTZ for H. pylori: ≤8 μg/mL for susceptible, and >8 μg/mL for resistant, according to EUCAST

^cLEV: MIC breakpoint of LEV for H. pylori: ≤1 μg/mL for susceptible, and >1 μg/mL for resistant, according to EUCAST

^dAMX: MIC breakpoint of AMX for H. pylori: ≤0.125 μg/mL for susceptible, and >0.125 μg/mL for resistant, according to EUCAST

^eMDR, multidrug-resistant, defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories