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Schematic diagram of domains in ICP27. The characterized domains include an NES, an NLS, and an RGG-box type RNA-binding motif, three KH motifs (KH1, KH2, and KH3), and an SM motif. Also shown is the position of mutations described here. These are the ts mutation R480H, the Fmr-like mutation in KH1, F303N, and the mutation DD32AA in the proposed ECS domain resembling the alterations that disrupt the inhibitory sequence in NS1.
