Fig. 2. Early parenteral protein and IGFBP-3 levels are associated with Late IGF-1 levels.

Relationships between IGF-1 at 35 weeks PMA and (a) average parenteral protein intake during first week of life (β −14.47 [−23.97, −4.96] p = 0.004), (b) day of life full enteral feeds are achieved (β −0.91 [0.91, 1.48] p = 0.002), (c) IGFBP-3 at 1 week of life (β 19.07 [7.73, 30.41] p = 0.001), (d) IGFBP-3 at 35 weeks PMA (β 0.02 [0.01, 0.02] p < 0.001). Strength of relationship represented by linear regression line. IGF-1: insulin-like growth factor 1, IGFBP-3: insulin-like growth factor binding protein 3, PN: parenteral nutrition, DOL: day of life, PMA: postmenstrual age, Early parenteral protein: g/kg parenteral protein days 2–8 of life.