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. Author manuscript; available in PMC: 2024 Aug 25.
Published in final edited form as: Pediatr Res. 2024 Jan 8;96(2):402–408. doi: 10.1038/s41390-023-02970-y

Fig. 3. Early Markers Associated with IGF-1/IGFBP-3 at 35 weeks PMA.

Fig. 3

Strength of association represented by β-coefficient. Closed/gray shapes (#): early parenteral protein intake did not significantly mediate the relationship between IGFBP-3 at DOL 7 and IGF-1 at 35 weeks PMA (−4.942, −15.716 to 0.59, p = 0.20) measured by Bootstrap test. Green line: positive associations, Red line: negative associations. IGF-1: insulin-like growth factor 1, IGFBP-3: insulin-like growth factor binding protein 3, SNAP-II: Score for Neonatal Acute Physiology, DOL: day of life, PMA: postmenstrual age, Early parenteral protein: g/kg parenteral protein days 2–8 of life. *p < 0.05, **p < 0.01, ***p < 0.001.