Table 2.

Associations between growth, body composition and IGF-1/IGFBP-3 Levels in VLBW Infants.

Measure	Variable	IGF-1 (n = 44 DOL 7, n = 39 35 wk PMA)			IGFBP-3 (n = 45 DOL 7, n = 43 35 wk PMA)
		Time	β (95% CI)	p-value	Time	β (95% CI)	p-value
Growth	Birth weight, z-score
		DOL 7	1.99 (−0.92, 4.91)	0.177	DOL 7	0.05 (−0.04, 0.14)	0.272
		35 weeks PMA	0.39 (−4.33, 5.11)	0.869	35 weeks PMA	0.07 (−0.04, 0.19)	0.215
	Birth length, z-score
		DOL 7	1.42 (−0.85, 3.7)	0.215	DOL 7	0.04 (−0.03, 0.11)	0.230
		35 weeks PMA	2.81 (−0.59, 6.21)	0.103	35 weeks PMA	0.11 (0.02, 0.2)	0.014
	Weight at discharge, z-score
		DOL 7	0.3 (0, 0.06)	0.086	DOL 7	0.74 (−0.77, 2.25)	0.326
		35 weeks PMA	0.01 (−0.02, 0.03)	0.433	35 weeks PMA	0.75 (−0.13, 1.62)	0.091
	Length at discharge, z-score
		DOL 7	0.03 (−0.01, 0.06)	0.106	DOL 7	1.41 (−0.16, 2.99)	0.078
		35 weeks PMA	0.01 (−0.01, 0.04)	0.271	35 weeks PMA	1.1 (0.17, 2.03)	0.022
	OFC at discharge, z-score
		DOL 7	0.02 (−0.01, 0.05)	0.231	DOL 7	0.69 (−0.81, 2.2)	0.358
		35 weeks PMA	0 (−0.03, 0.02)	0.755	35 weeks PMA	−0.02 (−0.96, 0.91)	0.959
Body Composition	Fat mass at discharge, z-score
		DOL 7	0.07 (0, 0.15)	0.053	DOL 7	0.59 (−2.74, 3.92)	0.722
		35 weeks PMA	0.03 (−0.03, 0.08)	0.329	35 weeks PMA	0.87 (−1, 2.75)	0.352
	Fat free mass at discharge, z-score
		DOL 7	0.03 (−0.02, 0.07)	0.200	DOL 7	1.44 (−0.45, 3.32)	0.131
		35 weeks PMA	0.01 (−0.02, 0.04)	0.451	35 weeks PMA	1 (−0.07, 2.08)	0.066
	Percent body fat at discharge, %
		DOL 7	0.03 (−0.04, 0.1)	0.464	DOL 7	0.3 (−2.75, 3.34)	0.844
		35 weeks PMA	0.02 (−0.03, 0.06)	0.494	35 weeks PMA	0.35 (−1.34, 2.04)	0.677
IGF-1/IGFBP-3 Levels	Early IGF-1
					DOL 7	0.01 (0.01, 0.02)	<0.001
		35 weeks PMA	0.1 (−0.36, 0.55)	0.676	35 weeks PMA	0.01 (0, 0.02)	0.126
	Early IGFBP-3
		DOL 7	0.01 (0.01, 0.02)	<0.001
		35 weeks PMA	19.07 (7.73, 30.41)	0.001	35 weeks PMA	0.56 (0.28, 0.84)	<0.001

All variables were studied separately and adjusted for birth gestational age, PMA at DOL 7/35 weeks, sex, and study arm (intervention vs control).

DOL Day of life, PMA Postmenstrual age.