Figure 2.

Differential expression of MSH-2, but not MSH-6, MLH-1, and PMS-2, associates with disease-specific survival in cervical cancer. (A): Tumors were defined as ‘low’ or ‘high’ for each of the mismatch repair (MMR) proteins. Low and high MMR protein expression was defined based on staining index (SI) 0–9. (B–E) Disease-specific survival relative to MSH-2 (B), MSH-6 (C), MLH-1 (D), and PMS-2 (E) protein levels. Best cut-off for predicting disease-specific survival (Youden index) was applied (MSH-2: ‘low’ SI 0–4 and ‘high’ SI 6–9, MLH-1: ‘low’ SI 0–6 and ‘high’ SI 9, MSH-6: ‘low’ SI 0–6 and ‘high’ SI 9, PMS-2: ‘low’ SI 0–3 and ‘high’ SI 4–9). P-values are given by log-rank (Mantel–Cox) test. Numbers in parentheses indicate total number of patients/events.