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(A) Trial Design – Development of GFLIO ± DM ± Target Drugs. (B) Palliative Regimen. - Advanced Cholangiocarcinoma Palliative Regimen: All q2 weeks; -Parenthesis (): reference dosage reduction as needed for safety. - Bevacizumab replaces cetuximab at the time of progression. - Granulocyte Colony Stimulating Factor was added (300 mcg) on days 7 and 8 or 15 and 16 if the nadir neutrophil count is or will be <1000/µl or remains < 1250/µl, respectively.
