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. 2024 Jun 24;11:1411354. doi: 10.3389/fcvm.2024.1411354

Figure 4.

Figure 4

Abolished exercise-induced cardiac growth in β2−/− mice. (A, B) Summary of heart weight (HW), normalized to tibia length (TL; A) or body weight (BW; B), determined by gravimetric measurements at necropsy of sedentary and exercise-trained wild-type (wt) and β2−/− mice. *p < 0.05, ns: p > 0.05 (A); **p < 0.01, ns: p > 0.05 (B), wt exercise vs. sedentary, one-way ANOVA with Dunn's multiple comparisons test, n = 6–7 mice. (C) Summary of relative change in expression (exercise vs. sedentary) of CEBPB, CITED4, and NFATC2 transcripts in hearts from wt and β2−/− mice. *p < 0.05, ns: p > 0.05, Wilcoxon test. (D) Representative fluorescence images of transverse left ventricular sections from wt and β2−/− mice stained with alexa fluor 555-conjugated wheat germ agglutinin (membrane) and DAPI (nuclei). Scale bars represent 20 μm. (E) Relative frequency distributions showing myocyte cross-sectional areas in hearts from sedentary and exercised wt and β2−/− mice. n = 665–811 total myocytes from 6 to 8 mice. (F) Summary of cardiac myocyte cross-sectional area in wt and β2−/− sedentary and exercise-trained mice. *p > 0.05, ns: p > 0.05, one-way ANOVA with Holm-Šídák's multiple comparisons test n = 6–8 mice.