Table 2.
Comparison of echocardiographic parameters in wild-type and Kvβ2−/− exercised and sedentary mice.
| Measurement | Wild-type | Kvβ2−/− | ||
|---|---|---|---|---|
| Sedentary | Exercise | Sedentary | Exercise | |
| HR (BPM) | 415 ± 7 | 424 ± 6 | 411 ± 10 | 438 ± 10 |
| Endocardial values | ||||
| EDV (µl) | 40.3 ± 2.6 | 37.8 ± 2.2 | 41.6 ± 1.6 | 40.0 ± 1.9 |
| ESV (µl) | 13.0 ± 1.2 | 10.7 ± 0.6 | 16.3 ± 1.4 | 12.5 ± 0.7 * |
| SV (µl) | 27.3 ± 1.9 | 27.3 ± 1.9 | 25.5 ± 1.4 | 27.7 ± 1.8 |
| EF (%) | 67.5 ± 1.9 | 71.5 ± 1.1 | 61.3 ± 2.6 | 68.5 ± 1.9 * |
| FS (%) | 36.2 ± 1.5 | 44.4 ± 1.9 ** | 35.3 ± 1.8 | 41.7 ± 1.7 * |
| CO (ml/min) | 11.3 ± 0.6 | 11.5 ± 0.8 | 10.5 ± 0.7 | 12.1 ± 0.8 |
| Chamber diameter | ||||
| LVIDd (mm) | 3.7 ± 0.1 | 3.6 ± 0.1 | 3.5 ± 0.1 | 3.6 ± 0.1 |
| LVIDs (mm) | 2.4 ± 0.1 | 2.0 ± 0.1 * | 2.3 ± 0.1 | 2.1 ± 0.1 |
| Wall Thickness | ||||
| LVPWd (mm) | 0.92 ± 0.06 | 1.25 ± 0.11 ** | 0.89 ± 0.04 | 0.83 ± 0.08 |
| LVPWs (mm) | 1.32 ± 0.03 | 1.65 ± 0.08 ** | 1.29 ± 0.04 | 1.32 ± 0.07 |
| LVAWd (mm) | 1.08 ± 0.06 | 1.13 ± 0.08 | 1.01 ± 0.05 | 1.10 ± 0.04 |
| LVAWs (mm) | 1.52 ± 0.07 | 1.65 ± 0.08 | 1.40 ± 0.05 | 1.65 ± 0.06 * |
| RWT | 0.49 ± 0.04 | 0.70 ± 0.07 * | 0.51 ± 0.03 | 0.47 ± 0.05 |
HR, heart rate; BPM, beats per minute; EDV, end diastolic volume; ESV, end systolic volume; SV, stroke volume; EF, ejection fraction; FS, fractional shortening; CO, cardiac output; LVIDd, left ventricular inner diameter at diastole; LVIDs, left ventricular inner diameter at systole; LVPWd, left ventricular posterior wall at diastole; LVPWs, left ventricular posterior wall at systole; LVAWd, left ventricular anterior wall at diastole; LVAWs, left ventricular anterior wall at systole; RWT, relative wall thickness.
*
p < 0.05.
**
p < 0.01, one-way ANOVA with Šídák's multiple comparisons test, n = 6–8 mice.