Figure 6.

Disruption of S100A8-CD147 pathway improves chemotherapy efficiency in vivo

(A) Tumor growth curves of xenografts derived from co-transplantation of control and CD147-knockout CAFs with PCs and treated with chemotherapeutics or vehicle reagents (n = 4 per group). Data are presented as mean ± SD. p values are determined using two-tailed Student’s t test.

(B) Representative images of H&E, MTS, αSMA, cleaved-Caspase 3, and S100A8 staining of tumor tissues in (A). Scale bar, 100 μm.

(C) Quantification of (B). Data are presented as mean ± SEM. p values are determined using two-tailed Student’s t test.

(D) Tumor growth curves of xenografts of PDX-19 treated with AC-73 and control solvent and with chemotherapeutics or vehicle reagents (n = 4 per group). Data are presented as mean ± SD. p values are determined using two-tailed Student’s t test.

(E) Representative images of H&E, MTS, αSMA, and cleaved-Caspase 3 staining of tumor tissues in (D). Scale bar, 100 μm.

(F) Quantification of (E). Data are presented as mean ± SEM. p values are determined using two-tailed Student’s t test. For all panels, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, and n.s., not significant. Each assay for western blot had three biological repeats. See also Figure S7.