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. 2024 May 31;6(4):fcae190. doi: 10.1093/braincomms/fcae190

Figure 3.

Figure 3

Polygenic risk score from Parkinson’s disease, Alzheimer’s disease and dementia with Lewy bodies GWAS. Violin plot comparing z-transformed (A) Parkinson's disease, (B) Alzheimer's disease and (C) dementia with Lewy body polygenic risk score (PRS) distributions in Lewy body disease with dementia (LBD-D, n = 2908) with those without (LBD-ND, n = 4896). The centreline of the box plot represents the median, and the box limits are the interquartile range. Dots correspond to outliers. A general linear regression model was applied to assess the odds PRS-predicted dementia. High Parkinson’s disease PRS predicts lower odds of developing dementia (OR = 0.74, 95% CI = 0.56–0.98, P = 0.03), while high dementia with Lewy bodies PRS predicts increased odds of developing dementia (OR = 2.69, 95% CI = 0.69–10.42, P = 0.01).